suramin has been researched along with Edema in 3 studies
Suramin: A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.
suramin : A member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years.
Edema: Abnormal fluid accumulation in TISSUES or body cavities. Most cases of edema are present under the SKIN in SUBCUTANEOUS TISSUE.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Focal brain ischemia was produced by unilateral occlusion and transection of the middle cerebral artery (MCAT) and bilateral occlusion of the common carotid arteries (CCA)." | 5.31 | Suramin reduces infarct volume in a model of focal brain ischemia in rats. ( Jones, SC; Kharlamov, A; Kim, DK, 2002) |
| "Suramin was efficient to decrease the lethality in a dose-dependent way." | 1.39 | Neutralization of Apis mellifera bee venom activities by suramin. ( Calil-Elias, S; El-Kik, CZ; Fernandes, FF; Fonseca, TF; Gaban, GA; Martinez, AM; Melo, PA; Oliveira, SD; Silva, CL; Tomaz, MA, 2013) |
| "Focal brain ischemia was produced by unilateral occlusion and transection of the middle cerebral artery (MCAT) and bilateral occlusion of the common carotid arteries (CCA)." | 1.31 | Suramin reduces infarct volume in a model of focal brain ischemia in rats. ( Jones, SC; Kharlamov, A; Kim, DK, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (33.33) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| El-Kik, CZ | 1 |
| Fernandes, FF | 1 |
| Tomaz, MA | 1 |
| Gaban, GA | 1 |
| Fonseca, TF | 1 |
| Calil-Elias, S | 1 |
| Oliveira, SD | 1 |
| Silva, CL | 1 |
| Martinez, AM | 1 |
| Melo, PA | 1 |
| Kharlamov, A | 1 |
| Jones, SC | 1 |
| Kim, DK | 1 |
| Ziganshina, LE | 1 |
| Ziganshin, AU | 1 |
| Hoyle, CH | 1 |
| Burnstock, G | 1 |
3 other studies available for suramin and Edema
| Article | Year |
|---|---|
Neutralization of Apis mellifera bee venom activities by suramin.
Topics: Animals; Antivenins; Bee Venoms; Capillary Permeability; Cells, Cultured; Creatine Kinase; Edema; En | 2013 |
Suramin reduces infarct volume in a model of focal brain ischemia in rats.
Topics: Animals; Brain; Brain Ischemia; Carotid Arteries; Disease Models, Animal; Dose-Response Relationship | 2002 |
Acute paw oedema formation induced by ATP: re-evaluation of the mechanisms involved.
Topics: Adenosine Triphosphate; Animals; Dose-Response Relationship, Drug; Edema; Histamine; Inflammation; M | 1996 |