Page last updated: 2024-11-04

suramin and Edema

suramin has been researched along with Edema in 3 studies

Suramin: A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.
suramin : A member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years.

Edema: Abnormal fluid accumulation in TISSUES or body cavities. Most cases of edema are present under the SKIN in SUBCUTANEOUS TISSUE.

Research Excerpts

ExcerptRelevanceReference
"Focal brain ischemia was produced by unilateral occlusion and transection of the middle cerebral artery (MCAT) and bilateral occlusion of the common carotid arteries (CCA)."5.31Suramin reduces infarct volume in a model of focal brain ischemia in rats. ( Jones, SC; Kharlamov, A; Kim, DK, 2002)
"Suramin was efficient to decrease the lethality in a dose-dependent way."1.39Neutralization of Apis mellifera bee venom activities by suramin. ( Calil-Elias, S; El-Kik, CZ; Fernandes, FF; Fonseca, TF; Gaban, GA; Martinez, AM; Melo, PA; Oliveira, SD; Silva, CL; Tomaz, MA, 2013)
"Focal brain ischemia was produced by unilateral occlusion and transection of the middle cerebral artery (MCAT) and bilateral occlusion of the common carotid arteries (CCA)."1.31Suramin reduces infarct volume in a model of focal brain ischemia in rats. ( Jones, SC; Kharlamov, A; Kim, DK, 2002)

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (33.33)18.2507
2000's1 (33.33)29.6817
2010's1 (33.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
El-Kik, CZ1
Fernandes, FF1
Tomaz, MA1
Gaban, GA1
Fonseca, TF1
Calil-Elias, S1
Oliveira, SD1
Silva, CL1
Martinez, AM1
Melo, PA1
Kharlamov, A1
Jones, SC1
Kim, DK1
Ziganshina, LE1
Ziganshin, AU1
Hoyle, CH1
Burnstock, G1

Other Studies

3 other studies available for suramin and Edema

ArticleYear
Neutralization of Apis mellifera bee venom activities by suramin.
    Toxicon : official journal of the International Society on Toxinology, 2013, Jun-01, Volume: 67

    Topics: Animals; Antivenins; Bee Venoms; Capillary Permeability; Cells, Cultured; Creatine Kinase; Edema; En

2013
Suramin reduces infarct volume in a model of focal brain ischemia in rats.
    Experimental brain research, 2002, Volume: 147, Issue:3

    Topics: Animals; Brain; Brain Ischemia; Carotid Arteries; Disease Models, Animal; Dose-Response Relationship

2002
Acute paw oedema formation induced by ATP: re-evaluation of the mechanisms involved.
    Inflammation research : official journal of the European Histamine Research Society ... [et al.], 1996, Volume: 45, Issue:2

    Topics: Adenosine Triphosphate; Animals; Dose-Response Relationship, Drug; Edema; Histamine; Inflammation; M

1996