suramin has been researched along with Di Guglielmo Disease in 2 studies
Suramin: A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.
suramin : A member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Levamisole, like Na3VO4, was found to increase the tyrosine phosphate levels of proteins of similar molecular weights in intact cells in both the presence and absence of a differentiation inducer." | 1.30 | The phosphatase inhibitors, orthovanadate and levamisole, inhibit induction of erythroid differentiation and abrogate the associated inhibition of glycolysis. ( Fuksina, I; Hellinger, N; Scher, BM; Scher, W; Waxman, S, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (50.00) | 18.7374 |
| 1990's | 1 (50.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Scher, BM | 1 |
| Fuksina, I | 1 |
| Hellinger, N | 1 |
| Waxman, S | 1 |
| Scher, W | 1 |
| Balzarini, J | 1 |
| Mitsuya, H | 1 |
| De Clercq, E | 1 |
| Broder, S | 1 |
2 other studies available for suramin and Di Guglielmo Disease
| Article | Year |
|---|---|
The phosphatase inhibitors, orthovanadate and levamisole, inhibit induction of erythroid differentiation and abrogate the associated inhibition of glycolysis.
Topics: Animals; Cell Differentiation; Dimethyl Sulfoxide; Erythropoiesis; Fructosediphosphates; Glycolysis; | 1998 |
Aurintricarboxylic acid and Evans Blue represent two different classes of anionic compounds which selectively inhibit the cytopathogenicity of human T-cell lymphotropic virus type III/lymphadenopathy-associated virus.
Topics: Animals; Aurintricarboxylic Acid; Azo Compounds; Benzhydryl Compounds; Cell Division; Cyclohexanecar | 1986 |