suramin has been researched along with Dengue in 2 studies
Suramin: A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.
suramin : A member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years.
Dengue: An acute febrile disease transmitted by the bite of AEDES mosquitoes infected with DENGUE VIRUS. It is self-limiting and characterized by fever, myalgia, headache, and rash. SEVERE DENGUE is a more virulent form of dengue.
| Excerpt | Relevance | Reference |
|---|---|---|
| " We have evaluated the antiviral effect of the sulfated polysaccharides, suramin, pentosan polysulfate (PPS) and PI-88, which are currently approved or in trial for clinical use, against dengue virus (DEN) and the encephalitic flaviviruses, Japanese encephalitis virus, West Nile virus, and Murray Valley encephalitis virus." | 3.73 | Antiviral effect of the heparan sulfate mimetic, PI-88, against dengue and encephalitic flaviviruses. ( Freeman, C; Lee, E; Lobigs, M; Pavy, M; Young, N, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Stevens, AJ | 1 |
| Gahan, ME | 1 |
| Mahalingam, S | 1 |
| Keller, PA | 1 |
| Lee, E | 1 |
| Pavy, M | 1 |
| Young, N | 1 |
| Freeman, C | 1 |
| Lobigs, M | 1 |
1 review available for suramin and Dengue
| Article | Year |
|---|---|
The medicinal chemistry of dengue fever.
Topics: Antiviral Agents; Dengue; Dengue Virus; Humans; Models, Molecular; Viral Proteins | 2009 |
1 other study available for suramin and Dengue
| Article | Year |
|---|---|
Antiviral effect of the heparan sulfate mimetic, PI-88, against dengue and encephalitic flaviviruses.
Topics: Animals; Antiviral Agents; Cell Line; Dengue; Dengue Virus; Disease Models, Animal; Drug Evaluation, | 2006 |