Page last updated: 2024-11-04

suramin and Dengue

suramin has been researched along with Dengue in 2 studies

Suramin: A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.
suramin : A member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years.

Dengue: An acute febrile disease transmitted by the bite of AEDES mosquitoes infected with DENGUE VIRUS. It is self-limiting and characterized by fever, myalgia, headache, and rash. SEVERE DENGUE is a more virulent form of dengue.

Research Excerpts

ExcerptRelevanceReference
" We have evaluated the antiviral effect of the sulfated polysaccharides, suramin, pentosan polysulfate (PPS) and PI-88, which are currently approved or in trial for clinical use, against dengue virus (DEN) and the encephalitic flaviviruses, Japanese encephalitis virus, West Nile virus, and Murray Valley encephalitis virus."3.73Antiviral effect of the heparan sulfate mimetic, PI-88, against dengue and encephalitic flaviviruses. ( Freeman, C; Lee, E; Lobigs, M; Pavy, M; Young, N, 2006)

Research

Studies (2)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (100.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Stevens, AJ1
Gahan, ME1
Mahalingam, S1
Keller, PA1
Lee, E1
Pavy, M1
Young, N1
Freeman, C1
Lobigs, M1

Reviews

1 review available for suramin and Dengue

ArticleYear
The medicinal chemistry of dengue fever.
    Journal of medicinal chemistry, 2009, Dec-24, Volume: 52, Issue:24

    Topics: Antiviral Agents; Dengue; Dengue Virus; Humans; Models, Molecular; Viral Proteins

2009

Other Studies

1 other study available for suramin and Dengue

ArticleYear
Antiviral effect of the heparan sulfate mimetic, PI-88, against dengue and encephalitic flaviviruses.
    Antiviral research, 2006, Volume: 69, Issue:1

    Topics: Animals; Antiviral Agents; Cell Line; Dengue; Dengue Virus; Disease Models, Animal; Drug Evaluation,

2006