suramin has been researched along with Demyelinating Diseases in 1 studies
Suramin: A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.
suramin : A member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years.
Demyelinating Diseases: Diseases characterized by loss or dysfunction of myelin in the central or peripheral nervous system.
| Excerpt | Relevance | Reference |
|---|---|---|
| " We conclude that: (1) serial electrophysiologic monitoring is helpful for early detection of suramin-induced neuropathy; and (2) fixed dosing schedule of suramin without adaptive control does not lead to an increased incidence of demyelinating neuropathy when compared to adaptively controlled dosing schedules." | 2.68 | Evaluation of neuropathy in patients on suramin treatment. ( Arora, R; Dhand, UK; Janisch, L; Kobayashi, K; Martin, B; Petersen, MV; Ratain, MJ; Soliven, B; Vogelzang, NJ; Vokes, EE, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Soliven, B | 1 |
| Dhand, UK | 1 |
| Kobayashi, K | 1 |
| Arora, R | 1 |
| Martin, B | 1 |
| Petersen, MV | 1 |
| Janisch, L | 1 |
| Vogelzang, NJ | 1 |
| Vokes, EE | 1 |
| Ratain, MJ | 1 |
1 trial available for suramin and Demyelinating Diseases
| Article | Year |
|---|---|
Evaluation of neuropathy in patients on suramin treatment.
Topics: Adult; Aged; Aged, 80 and over; Demyelinating Diseases; Female; Humans; Male; Middle Aged; Motor Neu | 1997 |