suramin has been researched along with Dementias, Transmissible in 2 studies
Suramin: A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.
suramin : A member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Prion diseases are fatal neurodegenerative infectious disorders for which no therapeutic or prophylactic regimens exist." | 2.44 | Strategies for eliminating PrP(c) as substrate for prion conversion and for enhancing PrP(Sc) degradation. ( Ertmer, A; Gilch, S; Nunziante, M; Schätzl, HM, 2007) |
| "Prion diseases are fatal and transmissible neurodegenerative disorders linked to an aberrant conformation of the cellular prion protein (PrP(c))." | 1.31 | Intracellular re-routing of prion protein prevents propagation of PrP(Sc) and delays onset of prion disease. ( Gilch, S; Groschup, MH; Lucassen, R; Muranyi, W; Nunziante, M; Riesner, D; Schätzl, HM; Spielhaupter, C; Tatzelt, J; Winklhofer, KF, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gilch, S | 2 |
| Nunziante, M | 2 |
| Ertmer, A | 1 |
| Schätzl, HM | 2 |
| Winklhofer, KF | 1 |
| Groschup, MH | 1 |
| Lucassen, R | 1 |
| Spielhaupter, C | 1 |
| Muranyi, W | 1 |
| Riesner, D | 1 |
| Tatzelt, J | 1 |
1 review available for suramin and Dementias, Transmissible
| Article | Year |
|---|---|
Strategies for eliminating PrP(c) as substrate for prion conversion and for enhancing PrP(Sc) degradation.
Topics: Animals; Anticholesteremic Agents; Cholesterol; Lovastatin; Prion Diseases; PrPC Proteins; PrPSc Pro | 2007 |
1 other study available for suramin and Dementias, Transmissible
| Article | Year |
|---|---|
Intracellular re-routing of prion protein prevents propagation of PrP(Sc) and delays onset of prion disease.
Topics: Acids; Amidohydrolases; Animals; Cell Compartmentation; Detergents; Golgi Apparatus; Intracellular F | 2001 |