suramin has been researched along with Delayed Hypersensitivity in 7 studies
Suramin: A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.
suramin : A member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Suramin treatment was most effective in suppressing EAU when started concurrently with immunization (afferent)." | 5.29 | Suramin treatment suppresses induction of experimental autoimmune uveoretinitis (EAU) in rodents. ( Caspi, RR; Chan, CC; Sartani, G; Silver, PB; Strassmann, G, 1995) |
| "Suramin treatment was most effective in suppressing EAU when started concurrently with immunization (afferent)." | 1.29 | Suramin treatment suppresses induction of experimental autoimmune uveoretinitis (EAU) in rodents. ( Caspi, RR; Chan, CC; Sartani, G; Silver, PB; Strassmann, G, 1995) |
| "Suramin was particularly effective when given during the effector phase of DTH: mice which were treated with this drug, 4 days after immunization, at the time of skin testing, exhibit negative or low DTH responses compared to control mice." | 1.27 | Effects of suramin on the immune responses to sheep red blood cells in mice. I. In vivo studies. ( Brandely, M; Hurtrel, B; Lagrange, P; Motta, I; Truffa-Bachi, P, 1985) |
| "Treatment with suramin, concomitantly or 1 day before, enhanced markedly the bacterial growth in spleen and liver, detected as early as 3 to 6 h after the challenge, the maximum being observed at 48 h in the liver." | 1.27 | Effects of suramin on the in vivo antimicrobial resistance against Listeria monocytogenes and Mycobacterium bovis (BCG) in mice. ( Brandely, M; Hurtrel, B; Lagrange, PH, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (71.43) | 18.7374 |
| 1990's | 1 (14.29) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (14.29) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sullivan, JA | 1 |
| Jankowska-Gan, E | 1 |
| Shi, L | 1 |
| Roenneburg, D | 1 |
| Hegde, S | 1 |
| Greenspan, DS | 1 |
| Wilkes, DS | 1 |
| Denlinger, LC | 1 |
| Burlingham, WJ | 1 |
| Sartani, G | 1 |
| Silver, PB | 1 |
| Strassmann, G | 1 |
| Chan, CC | 1 |
| Caspi, RR | 1 |
| Arora, MP | 1 |
| Crowle, AJ | 1 |
| Brandely, M | 2 |
| Lagrange, P | 1 |
| Hurtrel, B | 2 |
| Motta, I | 1 |
| Truffa-Bachi, P | 1 |
| Verdonck, LF | 1 |
| de Gast, GC | 1 |
| Lange, JM | 1 |
| Schuurman, HJ | 1 |
| Dekker, AW | 1 |
| Bast, BJ | 1 |
| Dénes, L | 1 |
| Hajós, G | 1 |
| Szporny, L | 1 |
| Szende, B | 1 |
| Lapis, K | 1 |
| Sipka, S | 1 |
| Szegedi, G | 1 |
| Lagrange, PH | 1 |
7 other studies available for suramin and Delayed Hypersensitivity
| Article | Year |
|---|---|
Differential requirement for P2X7R function in IL-17 dependent vs. IL-17 independent cellular immune responses.
Topics: Animals; Antineoplastic Agents; Autoimmunity; Collagen Type V; Flow Cytometry; Graft Rejection; Hear | 2014 |
Suramin treatment suppresses induction of experimental autoimmune uveoretinitis (EAU) in rodents.
Topics: Animals; Autoimmune Diseases; Eye Proteins; Female; Hypersensitivity, Delayed; Immunization; Immunog | 1995 |
Adjuvanticity of Evans blue dye: preliminary characterization of its mechanisms and mode of application in mice.
Topics: Adjuvants, Immunologic; Animals; Antigens; Antigens, Bacterial; Azo Compounds; Conalbumin; Dose-Resp | 1978 |
Effects of suramin on the immune responses to sheep red blood cells in mice. I. In vivo studies.
Topics: Animals; Antibody Formation; Erythrocytes; Female; Hypersensitivity, Delayed; Immunity, Cellular; Mi | 1985 |
Syngeneic leukocytes together with suramin failed to improve immunodeficiency in a case of transfusion-associated AIDS after syngeneic bone marrow transplantation.
Topics: Acquired Immunodeficiency Syndrome; Adult; Antigens, Viral; Blood Donors; Bone Marrow Transplantatio | 1988 |
The effect of thymopoietin 32-34 (TP3) on suramin-induced inhibition on delayed type hypersensitivity in guinea pigs.
Topics: Animals; Guinea Pigs; Hypersensitivity, Delayed; Immunity, Cellular; Oligopeptides; Peptide Fragment | 1987 |
Effects of suramin on the in vivo antimicrobial resistance against Listeria monocytogenes and Mycobacterium bovis (BCG) in mice.
Topics: Animals; Female; Hypersensitivity, Delayed; Immunity, Innate; Listeriosis; Lymphoid Tissue; Mice; Mi | 1986 |