suramin has been researched along with Day Blindness in 2 studies
Suramin: A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.
suramin : A member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In 1959 a population of 638 persons over the age of seven years, suffering from heavy endemic onchocerciasis in the Sudan-Savannah of West Africa was examined, and approximately half were allotted to a group for treatment with suramin (up to a total of 4-2 g for healthy adults)." | 7.65 | The natural history of ocular onchocerciasis over a period of 14--15 years and the effect on this of a single course of suramin therapy. ( Budden, FH, 1976) |
| "In 1959 a population of 638 persons over the age of seven years, suffering from heavy endemic onchocerciasis in the Sudan-Savannah of West Africa was examined, and approximately half were allotted to a group for treatment with suramin (up to a total of 4-2 g for healthy adults)." | 3.65 | The natural history of ocular onchocerciasis over a period of 14--15 years and the effect on this of a single course of suramin therapy. ( Budden, FH, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (50.00) | 18.7374 |
| 1990's | 1 (50.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hemady, RK | 1 |
| Sinibaldi, VJ | 1 |
| Eisenberger, MA | 1 |
| Budden, FH | 1 |
2 other studies available for suramin and Day Blindness
| Article | Year |
|---|---|
Ocular symptoms and signs associated with suramin sodium treatment for metastatic cancer of the prostate.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Corneal Diseases; Eye Diseases; Humans; Infus | 1996 |
The natural history of ocular onchocerciasis over a period of 14--15 years and the effect on this of a single course of suramin therapy.
Topics: Adolescent; Adult; Child; Eye Diseases; Female; Follow-Up Studies; Humans; Male; Microfilariae; Onch | 1976 |