suramin has been researched along with Corneal Diseases in 3 studies
Suramin: A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.
suramin : A member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years.
Corneal Diseases: Diseases of the cornea.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Vortex keratopathy occurred in six patients given high-dose intravenous suramin for adrenocortical carcinoma." | 3.67 | Suramin keratopathy. ( Chan, CC; Holland, EJ; Kuwabara, T; LaRocca, R; McAtee, N; Myers, CE; Nussenblatt, RN; Palestine, AG; Stein, CA; Thomas, R, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (66.67) | 18.7374 |
| 1990's | 1 (33.33) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hemady, RK | 1 |
| Sinibaldi, VJ | 1 |
| Eisenberger, MA | 1 |
| Holland, EJ | 1 |
| Stein, CA | 1 |
| Palestine, AG | 1 |
| LaRocca, R | 1 |
| Chan, CC | 1 |
| Kuwabara, T | 1 |
| Myers, CE | 1 |
| Thomas, R | 1 |
| McAtee, N | 1 |
| Nussenblatt, RN | 1 |
| Teich, SA | 1 |
| Handwerger, S | 1 |
| Mathur-Wagh, U | 1 |
| Yancovitz, S | 1 |
| Desnick, RJ | 1 |
| Mildvan, D | 1 |
3 other studies available for suramin and Corneal Diseases
| Article | Year |
|---|---|
Ocular symptoms and signs associated with suramin sodium treatment for metastatic cancer of the prostate.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Corneal Diseases; Eye Diseases; Humans; Infus | 1996 |
Suramin keratopathy.
Topics: Adrenal Cortex; Adrenal Gland Neoplasms; Adult; Carcinoma; Corneal Diseases; Female; Humans; Injecti | 1988 |
Toxic keratopathy associated with suramin therapy.
Topics: Acquired Immunodeficiency Syndrome; Corneal Diseases; Humans; Suramin | 1986 |