suramin has been researched along with Corneal Angiogenesis in 5 studies
Suramin: A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.
suramin : A member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The objective is to analyze the antiangiogenic mechanism of suramab, a pharmaceutical compound of bevacizumab and suramin, in a rabbit model of corneal angiogenesis." | 7.88 | Corneal Neovascularization: A Combined Approach of Bevacizumab and Suramin Showed Increased Antiangiogenic Effect Through Downregulation of BFGF and P ( Croxatto, JO; Gallo, JE; Lopez, ES; Ortiz, GA; Potilinski, C, 2018) |
| "To evaluate the effect of subconjunctival injection of suramin on corneal neovascularization in rabbits." | 7.76 | The effect of subconjunctival suramin on corneal neovascularization in rabbits. ( Chung, SK; Lee, HS, 2010) |
| "The objective is to analyze the antiangiogenic mechanism of suramab, a pharmaceutical compound of bevacizumab and suramin, in a rabbit model of corneal angiogenesis." | 3.88 | Corneal Neovascularization: A Combined Approach of Bevacizumab and Suramin Showed Increased Antiangiogenic Effect Through Downregulation of BFGF and P ( Croxatto, JO; Gallo, JE; Lopez, ES; Ortiz, GA; Potilinski, C, 2018) |
| "To evaluate the effect of subconjunctival injection of suramin on corneal neovascularization in rabbits." | 3.76 | The effect of subconjunctival suramin on corneal neovascularization in rabbits. ( Chung, SK; Lee, HS, 2010) |
| "Corneal neovascularization was induced in three groups of nine white New Zealand rabbits, applying a filter paper disk soaked in 1 M NaOH on the central cornea (Ormerod et al." | 1.37 | Suramab, a novel antiangiogenic agent, reduces tumor growth and corneal neovascularization. ( Croxatto, JO; Gallo, JE; Lopez, ES; Mazzolini, G; Rizzo, MM, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (20.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 4 (80.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lopez, ES | 3 |
| Ortiz, GA | 1 |
| Potilinski, C | 1 |
| Croxatto, JO | 2 |
| Gallo, JE | 3 |
| Quinteros, DA | 1 |
| Couto, JL | 1 |
| Maletto, BA | 1 |
| Allemandi, DA | 1 |
| Palma, SD | 1 |
| Lee, HS | 1 |
| Chung, SK | 1 |
| Rizzo, MM | 1 |
| Mazzolini, G | 1 |
| Rieck, P | 1 |
| Denis, J | 1 |
| Peters, D | 1 |
| Hartmann, C | 1 |
| Pouliquen, Y | 1 |
| Courtois, Y | 1 |
5 other studies available for suramin and Corneal Angiogenesis
| Article | Year |
|---|---|
Corneal Neovascularization: A Combined Approach of Bevacizumab and Suramin Showed Increased Antiangiogenic Effect Through Downregulation of BFGF and P
Topics: Animals; Bevacizumab; Blotting, Western; Cornea; Corneal Neovascularization; Disease Models, Animal; | 2018 |
Evaluation of the Performance of an Ophthalmic Thermosensitive Hydrogel Containing Combination of Suramin and Bevacizumab.
Topics: Administration, Ophthalmic; Angiogenesis Inhibitors; Animals; Bevacizumab; Corneal Neovascularizatio | 2016 |
The effect of subconjunctival suramin on corneal neovascularization in rabbits.
Topics: Angiogenesis Inhibitors; Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Bevaciz | 2010 |
Suramab, a novel antiangiogenic agent, reduces tumor growth and corneal neovascularization.
Topics: Angiogenesis Inhibitors; Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineo | 2011 |
Fibroblast growth factor 2, heparin and suramin reduce epithelial ulcer development in experimental HSV-1 keratitis.
Topics: Acyclovir; Administration, Topical; Animals; Corneal Neovascularization; Corneal Opacity; Drug Thera | 1997 |