suramin and Colitis
suramin has been researched along with Colitis in 2 studies
Suramin: A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.
suramin : A member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years.
Colitis: Inflammation of the COLON section of the large intestine (INTESTINE, LARGE), usually with symptoms such as DIARRHEA (often with blood and mucus), ABDOMINAL PAIN, and FEVER.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| "Strips from rabbits with colitis induced by 2,4,6-trinitrobenzenesulfonic acid (TNBS) were subjected to electrical field stimulation." | 3.72 | Mechanisms involved in the loss of excitatory post-stimulus responses by inflammation. ( Depoortere, I; Peeters, TL; Thielemans, L; Thijs, T, 2003) |
Research
Studies (2)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Depoortere, I | 1 |
| Thijs, T | 1 |
| Thielemans, L | 1 |
| Peeters, TL | 1 |
| Lomax, AE | 1 |
| O'Reilly, M | 1 |
| Neshat, S | 1 |
| Vanner, SJ | 1 |
Other Studies
2 other studies available for suramin and Colitis
| Article | Year |
|---|---|
Mechanisms involved in the loss of excitatory post-stimulus responses by inflammation.
Topics: Adenosine Triphosphate; Animals; Colitis; Cyclooxygenase Inhibitors; Electric Stimulation; Female; I | 2003 |
Sympathetic vasoconstrictor regulation of mouse colonic submucosal arterioles is altered in experimental colitis.
Topics: Adenosine Triphosphate; Adrenergic Agents; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; | 2007 |