Page last updated: 2024-11-04

suramin and Colitis

suramin has been researched along with Colitis in 2 studies

Suramin: A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.
suramin : A member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years.

Colitis: Inflammation of the COLON section of the large intestine (INTESTINE, LARGE), usually with symptoms such as DIARRHEA (often with blood and mucus), ABDOMINAL PAIN, and FEVER.

Research Excerpts

ExcerptRelevanceReference
"Strips from rabbits with colitis induced by 2,4,6-trinitrobenzenesulfonic acid (TNBS) were subjected to electrical field stimulation."3.72Mechanisms involved in the loss of excitatory post-stimulus responses by inflammation. ( Depoortere, I; Peeters, TL; Thielemans, L; Thijs, T, 2003)

Research

Studies (2)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (100.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Depoortere, I1
Thijs, T1
Thielemans, L1
Peeters, TL1
Lomax, AE1
O'Reilly, M1
Neshat, S1
Vanner, SJ1

Other Studies

2 other studies available for suramin and Colitis

ArticleYear
Mechanisms involved in the loss of excitatory post-stimulus responses by inflammation.
    Naunyn-Schmiedeberg's archives of pharmacology, 2003, Volume: 367, Issue:3

    Topics: Adenosine Triphosphate; Animals; Colitis; Cyclooxygenase Inhibitors; Electric Stimulation; Female; I

2003
Sympathetic vasoconstrictor regulation of mouse colonic submucosal arterioles is altered in experimental colitis.
    The Journal of physiology, 2007, Sep-01, Volume: 583, Issue:Pt 2

    Topics: Adenosine Triphosphate; Adrenergic Agents; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists;

2007