suramin has been researched along with Classic Globoid Cell Leukodystrophy in 2 studies
Suramin: A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.
suramin : A member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In vivo studies were carried out on dental tissues of rat incisor after a single injection of suramin, a drug which induces mucopolysaccharidosis-like disease." | 3.68 | [Lysosomal storage diseases, genetic or drug-induced? effect of glycosaminoglycan and sphingolipid disorders on dental tissues]. ( Bloch-Zupan, A; Goldberg, M; Gritli, A; Lécolle, S; Legrand, JM; Ruch, JV; Septier, D, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Goldberg, M | 2 |
| Septier, D | 2 |
| Lécolle, S | 2 |
| Vermelin, L | 1 |
| Bissila-Mapahou, P | 1 |
| Carreau, JP | 1 |
| Gritli, A | 2 |
| Bloch-Zupan, A | 2 |
| Legrand, JM | 1 |
| Ruch, JV | 1 |
1 review available for suramin and Classic Globoid Cell Leukodystrophy
| Article | Year |
|---|---|
Lipids in predentine and dentine.
Topics: Animals; Autoradiography; Collagen; Coloring Agents; Dentin; Dentinogenesis; Extracellular Matrix; H | 1995 |
1 other study available for suramin and Classic Globoid Cell Leukodystrophy
| Article | Year |
|---|---|
[Lysosomal storage diseases, genetic or drug-induced? effect of glycosaminoglycan and sphingolipid disorders on dental tissues].
Topics: Ameloblasts; Animals; Child; Dentin; Glycosaminoglycans; Humans; In Vitro Techniques; Leukodystrophy | 1993 |