suramin has been researched along with Cicatrix in 3 studies
Suramin: A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.
suramin : A member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years.
Cicatrix: The fibrous tissue that replaces normal tissue during the process of WOUND HEALING.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Muscle healing often is hindered by scar tissue formation after injury." | 1.33 | The use of suramin, an antifibrotic agent, to improve muscle recovery after strain injury. ( Chan, YS; Foster, W; Fu, FH; Huard, J; Li, Y, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (33.33) | 18.7374 |
| 1990's | 1 (33.33) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| GOUGEROT, H | 1 |
| CARTEAUD, A | 1 |
| Chan, YS | 1 |
| Li, Y | 1 |
| Foster, W | 1 |
| Fu, FH | 1 |
| Huard, J | 1 |
| Chamberlain, J | 1 |
| Shah, M | 1 |
| Ferguson, MW | 1 |
3 other studies available for suramin and Cicatrix
| Article | Year |
|---|---|
Vivid pemphigus recurring widely on an operative scar, healing again by Moranyl.
Topics: Cicatrix; Humans; Organic Chemicals; Pemphigus; Suramin | 1946 |
The use of suramin, an antifibrotic agent, to improve muscle recovery after strain injury.
Topics: Animals; Antineoplastic Agents; Cicatrix; Fibroblasts; Mice; Mice, Inbred C57BL; Muscle, Skeletal; S | 2005 |
The effect of suramin on healing adult rodent dermal wounds.
Topics: Administration, Cutaneous; Animals; Cell Death; Cell Division; Cells, Cultured; Cicatrix; Collagen; | 1995 |