suramin has been researched along with Chronic Disease in 10 studies
Suramin: A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.
suramin : A member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years.
Chronic Disease: Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care (Dictionary of Health Services Management, 2d ed). For epidemiological studies chronic disease often includes HEART DISEASES; STROKE; CANCER; and diabetes (DIABETES MELLITUS, TYPE 2).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Suramin is a compound that inhibits the interaction of several cytokines and growth factors with their receptors, but whether suramin inhibits the progression of renal fibrosis is unknown." | 5.37 | Suramin inhibits renal fibrosis in chronic kidney disease. ( Liu, N; Pang, M; Ponnusamy, M; Tolbert, E; Yan, H; Zhuang, S, 2011) |
| "Suramin is a compound that inhibits the interaction of several cytokines and growth factors with their receptors, but whether suramin inhibits the progression of renal fibrosis is unknown." | 1.37 | Suramin inhibits renal fibrosis in chronic kidney disease. ( Liu, N; Pang, M; Ponnusamy, M; Tolbert, E; Yan, H; Zhuang, S, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (70.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (20.00) | 29.6817 |
| 2010's | 1 (10.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Liu, N | 1 |
| Tolbert, E | 1 |
| Pang, M | 1 |
| Ponnusamy, M | 1 |
| Yan, H | 1 |
| Zhuang, S | 1 |
| Kimura, H | 1 |
| Meguro, T | 1 |
| Badr, A | 1 |
| Zhang, JH | 1 |
| THIEL, E | 1 |
| Jennings, FW | 3 |
| Urquhart, GM | 2 |
| Murray, PK | 1 |
| Miller, BM | 1 |
| Lluel, P | 1 |
| Barras, M | 1 |
| Palea, S | 1 |
| Mahmoud, AA | 1 |
| Warren, KS | 1 |
| Binz, G | 1 |
| Neitz, WO | 1 |
| McCully, M | 1 |
10 other studies available for suramin and Chronic Disease
| Article | Year |
|---|---|
Suramin inhibits renal fibrosis in chronic kidney disease.
Topics: Actins; Animals; Antineoplastic Agents; Cells, Cultured; Chronic Disease; Disease Models, Animal; Di | 2011 |
Suramin-induced reversal of chronic cerebral vasospasm in experimental subarachnoid hemorrhage.
Topics: Adenosine Triphosphate; Animals; Antineoplastic Agents; Chronic Disease; Dogs; Female; Male; Oxyhemo | 2002 |
[The treatment of chronic recurrent urticaria with germanin].
Topics: Chronic Disease; Humans; Suramin; Urticaria | 1955 |
The use of 2-substituted 5-nitroimidazoles in the treatment of chronic murine Trypanosoma brucei infections with central nervous system involvement.
Topics: Animals; Antiprotozoal Agents; Brain; Chronic Disease; Drug Therapy, Combination; Female; Mice; Mice | 1984 |
The use of the 2 substituted 5-nitroimidazole, Fexinidazole (Hoe 239) in the treatment of chronic T. brucei infections in mice.
Topics: Animals; Antiprotozoal Agents; Chronic Disease; Diminazene; Drug Therapy, Combination; Female; Mice; | 1983 |
Cholinergic and purinergic contribution to the micturition reflex in conscious rats with long-term bladder outlet obstruction.
Topics: Animals; Atropine; Cholinergic Fibers; Chronic Disease; Drug Combinations; Electric Stimulation; Fem | 2002 |
Algorithms in the diagnosis and management of exotic diseases. XI. African trypanosomiases.
Topics: Acute Disease; Blood; Blood Sedimentation; Cerebrospinal Fluid; Chronic Disease; Humans; Lymph Nodes | 1976 |
Chemotherapy of chronic trypanosomiasis: the failure of ketoconazole to cure murine infections of Trypanosoma brucei with central nervous system involvement.
Topics: Animals; Central Nervous System Diseases; Chronic Disease; Drug Therapy, Combination; Ketoconazole; | 1988 |
Observations on levels of immunoglobulin M in confirmed cases of Trypanosoma rhodesiense infection in the Lambwe Valley.
Topics: Arsenicals; Chronic Disease; Humans; Immunoglobulin M; Kenya; Suramin; Time Factors; Triazines; Tryp | 1972 |
Clinicopathological study on experimental Trypanosoma brucei infections in horses. 1. Development of clinically recognizable nervous symptoms in nagana-infected horses treated with subcurative doses of Antrypol and Berenil.
Topics: Acetates; Amidines; Animals; Azo Compounds; Brain; Chronic Disease; Glycine; Horse Diseases; Horses; | 1971 |