suramin has been researched along with Chickungunya Fever in 6 studies
Suramin: A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.
suramin : A member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years.
| Excerpt | Relevance | Reference |
|---|---|---|
| "It causes the Ebola virus disease (EDV), formerly known as Ebola hemorrhagic fever in humans and has a mortality rate of up to 70 %." | 1.43 | Suramin is a potent inhibitor of Chikungunya and Ebola virus cell entry. ( Beck, S; Becker, S; Biedenkopf, N; Henß, L; Schnierle, BS; Sliva, K; Weber, C; Weidner, T, 2016) |
| "Suramin is a symmetric polyanionic naphthylurea that is widely used in the clinical treatment of parasite infections." | 1.42 | Suramin Inhibits Chikungunya Virus Entry and Transmission. ( Ho, YJ; Kuo, SC; Lin, CC; Lin, LI; Lu, JW; Wang, YM; Wu, TY, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 5 (83.33) | 24.3611 |
| 2020's | 1 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Albulescu, IC | 2 |
| White-Scholten, L | 1 |
| Tas, A | 1 |
| Hoornweg, TE | 1 |
| Ferla, S | 1 |
| Kovacikova, K | 2 |
| Smit, JM | 1 |
| Brancale, A | 1 |
| Snijder, EJ | 1 |
| van Hemert, MJ | 2 |
| Lu, JW | 2 |
| Hsieh, PS | 1 |
| Lin, CC | 3 |
| Hu, MK | 1 |
| Huang, SM | 1 |
| Wang, YM | 3 |
| Liang, CY | 1 |
| Gong, Z | 1 |
| Ho, YJ | 3 |
| Hwu, JR | 1 |
| Gupta, NK | 1 |
| Tsay, SC | 1 |
| Huang, WC | 1 |
| Wu, TY | 2 |
| Lin, LI | 1 |
| Kuo, SC | 2 |
| Chang, TY | 1 |
| Lai, ZZ | 1 |
| Tsui, PY | 1 |
| Henß, L | 1 |
| Beck, S | 1 |
| Weidner, T | 1 |
| Biedenkopf, N | 1 |
| Sliva, K | 1 |
| Weber, C | 1 |
| Becker, S | 1 |
| Schnierle, BS | 1 |
6 other studies available for suramin and Chickungunya Fever
| Article | Year |
|---|---|
Suramin Inhibits Chikungunya Virus Replication by Interacting with Virions and Blocking the Early Steps of Infection.
Topics: Animals; Antiviral Agents; Binding Sites; Chikungunya Fever; Chikungunya virus; Chlorocebus aethiops | 2020 |
Synergistic effects of combination treatment using EGCG and suramin against the chikungunya virus.
Topics: Antiviral Agents; Catechin; Chikungunya Fever; Chikungunya virus; Dose-Response Relationship, Drug; | 2017 |
Bis(benzofuran-thiazolidinone)s and bis(benzofuran-thiazinanone)s as inhibiting agents for chikungunya virus.
Topics: Animals; Antiviral Agents; Benzofurans; Cell Line; Chikungunya Fever; Chikungunya virus; Chlorocebus | 2017 |
Suramin Inhibits Chikungunya Virus Entry and Transmission.
Topics: Animals; Antiviral Agents; Cell Line; Chikungunya Fever; Chikungunya virus; Models, Molecular; Molec | 2015 |
Suramin treatment reduces chikungunya pathogenesis in mice.
Topics: Animals; Antiviral Agents; Chikungunya Fever; Chikungunya virus; Disease Models, Animal; Foot; Mice; | 2016 |
Suramin is a potent inhibitor of Chikungunya and Ebola virus cell entry.
Topics: Animals; Antiviral Agents; Cell Line; Chikungunya Fever; Chikungunya virus; Ebolavirus; Hemorrhagic | 2016 |