suramin and Chancre
suramin has been researched along with Chancre in 3 studies
Suramin: A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.
suramin : A member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years.
Chancre: The primary sore of syphilis, a painless indurated, eroded papule, occurring at the site of entry of the infection.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| " He presented with an inoculation chancre and was treated with suramin within four days of fever onset." | 3.78 | Human African trypanosomiasis in a Belgian traveller returning from the Masai Mara area, Kenya, February 2012. ( Asselman, V; Clerinx, J; Lejon, V; Maes, MB; Van de Casteele, S; Vlieghe, E, 2012) |
| "In January 2012, a case of Human African Trypanosomiasis (HAT) has been identified in Germany in a traveller returning from the Masai Mara area in Kenya." | 1.38 | Trypanosoma brucei rhodesiense infection in a German traveller returning from the Masai Mara area, Kenya, January 2012. ( Brodt, HR; Gottig, S; Just-Nuebling, G; Kleine, C; Wichelhaus, T; Wolf, T, 2012) |
| "Human African trypanosomiasis (sleeping sickness) is a parasitic infection transmitted by day-biting tsetse flies." | 1.33 | African trypanosomiasis in a British soldier. ( Croft, AM; Friend, HM; Jackson, CJ; Minton, EJ, 2006) |
Research
Studies (3)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 2 (66.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Wolf, T | 1 |
| Wichelhaus, T | 1 |
| Gottig, S | 1 |
| Kleine, C | 1 |
| Brodt, HR | 1 |
| Just-Nuebling, G | 1 |
| Clerinx, J | 1 |
| Vlieghe, E | 1 |
| Asselman, V | 1 |
| Van de Casteele, S | 1 |
| Maes, MB | 1 |
| Lejon, V | 1 |
| Croft, AM | 1 |
| Jackson, CJ | 1 |
| Friend, HM | 1 |
| Minton, EJ | 1 |
Other Studies
3 other studies available for suramin and Chancre
| Article | Year |
|---|---|
Trypanosoma brucei rhodesiense infection in a German traveller returning from the Masai Mara area, Kenya, January 2012.
Topics: Animals; Chancre; Diagnosis, Differential; Fever; Fluorescent Antibody Technique; Germany; Headache; | 2012 |
Human African trypanosomiasis in a Belgian traveller returning from the Masai Mara area, Kenya, February 2012.
Topics: Belgium; Chancre; Fever; Headache; Humans; Kenya; Male; Polymerase Chain Reaction; Suramin; Travel; | 2012 |
African trypanosomiasis in a British soldier.
Topics: Adult; Antinematodal Agents; Chancre; Erythema; Fever; Humans; Injections; Male; Military Personnel; | 2006 |