suramin has been researched along with Cerebromeningitis in 3 studies
Suramin: A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.
suramin : A member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In human African trypanosomiasis (HAT), the parasites invade the central nervous system (CNS), leading to the development of meningo-encephalitis and an irreversible demyelinating process, which kills the patient unless specific treatment is undertaken." | 1.32 | Megazol combined with suramin improves a new diagnosis index of the early meningo-encephalitic phase of experimental African trypanosomiasis. ( Bourdon, L; Bouteille, B; Buguet, A; Chevrier, C; Darsaud, A; Dumas, M, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (33.33) | 18.7374 |
| 1990's | 1 (33.33) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Darsaud, A | 1 |
| Chevrier, C | 1 |
| Bourdon, L | 1 |
| Dumas, M | 2 |
| Buguet, A | 1 |
| Bouteille, B | 2 |
| Keita, M | 1 |
| Enanga, B | 1 |
| Vallat, JM | 1 |
| Foulkes, JR | 1 |
3 other studies available for suramin and Cerebromeningitis
| Article | Year |
|---|---|
Megazol combined with suramin improves a new diagnosis index of the early meningo-encephalitic phase of experimental African trypanosomiasis.
Topics: Anemia; Animals; Body Weight; Drug Therapy, Combination; Eating; Hematocrit; Male; Meningoencephalit | 2004 |
Trypanosoma brucei brucei: a long-term model of human African trypanosomiasis in mice, meningo-encephalitis, astrocytosis, and neurological disorders.
Topics: Animals; Astrocytes; Brain; Choroid Plexus; Disease Models, Animal; Female; Meninges; Meningoencepha | 1997 |
An evaluation of prednisolone as a routine adjunct to the treatment of T. rhodesiense.
Topics: Adult; Arsenicals; Child; Drug Administration Schedule; Drug Evaluation, Preclinical; Humans; Melars | 1975 |