suramin has been researched along with Central Nervous System Neoplasms in 1 studies
Suramin: A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.
suramin : A member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years.
Central Nervous System Neoplasms: Benign and malignant neoplastic processes that arise from or secondarily involve the brain, spinal cord, or meninges.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To determine the toxicity, efficacy, and pharmacology of suramin in patients with recurrent or progressive recurrent high-grade gliomas." | 9.09 | Toxicity, efficacy, and pharmacology of suramin in adults with recurrent high-grade gliomas. ( Fisher, J; Grochow, LB; Grossman, SA; Lesser, G; Phuphanich, S; Piantadosi, S; Rozental, J, 2001) |
| "To determine the toxicity, efficacy, and pharmacology of suramin in patients with recurrent or progressive recurrent high-grade gliomas." | 5.09 | Toxicity, efficacy, and pharmacology of suramin in adults with recurrent high-grade gliomas. ( Fisher, J; Grochow, LB; Grossman, SA; Lesser, G; Phuphanich, S; Piantadosi, S; Rozental, J, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Grossman, SA | 1 |
| Phuphanich, S | 1 |
| Lesser, G | 1 |
| Rozental, J | 1 |
| Grochow, LB | 1 |
| Fisher, J | 1 |
| Piantadosi, S | 1 |
1 trial available for suramin and Central Nervous System Neoplasms
| Article | Year |
|---|---|
Toxicity, efficacy, and pharmacology of suramin in adults with recurrent high-grade gliomas.
Topics: Adult; Aged; Antineoplastic Agents; Central Nervous System Neoplasms; Female; Glioma; Humans; Male; | 2001 |