suramin has been researched along with Central Nervous System Disease in 5 studies
Suramin: A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.
suramin : A member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Chemotherapy for human African trypanosomiasis (HAT), or sleeping sickness, is unreliable because of resistance, refraction and toxic and adverse side-effects." | 1.30 | Megazol combined with suramin: a chemotherapy regimen which reversed the CNS pathology in a model of human African trypanosomiasis in mice. ( Bouteille, B; Chauvière, G; Dumas, M; Enanga, B; Keita, M, 1998) |
| " Two other goats appeared to be cured with this dosage of suramin but later developed abnormal central nervous system (CNS) signs and parasitaemia." | 1.28 | Experimental infection of goats with Trypanosoma brucei ssp. and effects of treatment with suramin and Mel-B. ( Chumo, DA; Muriithi, RM; Mwangi, J; Reardon, MJ; Towett, S; Wellde, BT, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (60.00) | 18.7374 |
| 1990's | 2 (40.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Jennings, FW | 2 |
| Urquhart, GM | 1 |
| Murray, PK | 1 |
| Miller, BM | 1 |
| Enanga, B | 1 |
| Keita, M | 1 |
| Chauvière, G | 1 |
| Dumas, M | 1 |
| Bouteille, B | 1 |
| Malesker, MA | 1 |
| Boken, D | 1 |
| Ruma, TA | 1 |
| Vuchetich, PJ | 1 |
| Murphy, PJ | 1 |
| Smith, PW | 1 |
| Wellde, BT | 1 |
| Reardon, MJ | 1 |
| Chumo, DA | 1 |
| Muriithi, RM | 1 |
| Towett, S | 1 |
| Mwangi, J | 1 |
5 other studies available for suramin and Central Nervous System Disease
| Article | Year |
|---|---|
Treatment with suramin and 2-substituted 5-nitroimidazoles of chronic murine Trypanosoma brucei infections with central nervous system involvement.
Topics: Animals; Antiprotozoal Agents; Cattle; Central Nervous System Diseases; Drug Therapy, Combination; F | 1983 |
Megazol combined with suramin: a chemotherapy regimen which reversed the CNS pathology in a model of human African trypanosomiasis in mice.
Topics: Animals; Body Weight; Central Nervous System Diseases; Disease Models, Animal; Drug Evaluation, Prec | 1998 |
Rhodesian trypanosomiasis in a splenectomized patient.
Topics: Adult; Africa; Animals; Central Nervous System Diseases; Humans; Male; Melarsoprol; Splenectomy; Sur | 1999 |
Experimental infection of goats with Trypanosoma brucei ssp. and effects of treatment with suramin and Mel-B.
Topics: Animals; Arsenicals; Brain; Central Nervous System; Central Nervous System Diseases; Goat Diseases; | 1989 |
Chemotherapy of chronic trypanosomiasis: the failure of ketoconazole to cure murine infections of Trypanosoma brucei with central nervous system involvement.
Topics: Animals; Central Nervous System Diseases; Chronic Disease; Drug Therapy, Combination; Ketoconazole; | 1988 |