suramin has been researched along with Cardiovascular Diseases in 3 studies
Suramin: A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.
suramin : A member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years.
Cardiovascular Diseases: Pathological conditions involving the CARDIOVASCULAR SYSTEM including the HEART; the BLOOD VESSELS; or the PERICARDIUM.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Suramin is a polysulfonated naphthylurea, which was originally synthesized and designed as a treatment for trypanosomiasis and selected malignancies and metastatic diseases." | 2.47 | Tissue protective and anti-fibrotic actions of suramin: new uses of an old drug. ( Liu, N; Zhuang, S, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| von Kügelgen, I | 1 |
| Hoffmann, K | 1 |
| Bozaoglu, K | 1 |
| Curran, JE | 1 |
| Stocker, CJ | 1 |
| Zaibi, MS | 1 |
| Segal, D | 1 |
| Konstantopoulos, N | 1 |
| Morrison, S | 1 |
| Carless, M | 1 |
| Dyer, TD | 1 |
| Cole, SA | 1 |
| Goring, HH | 1 |
| Moses, EK | 1 |
| Walder, K | 1 |
| Cawthorne, MA | 1 |
| Blangero, J | 1 |
| Jowett, JB | 1 |
| Liu, N | 1 |
| Zhuang, S | 1 |
2 reviews available for suramin and Cardiovascular Diseases
| Article | Year |
|---|---|
Pharmacology and structure of P2Y receptors.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Brain; Cardiovascular Diseases; Humans; Micr | 2016 |
Tissue protective and anti-fibrotic actions of suramin: new uses of an old drug.
Topics: Apoptosis; Cardiovascular Diseases; Humans; Kidney; Liver Cirrhosis; Muscle, Skeletal; Neuroprotecti | 2011 |
1 other study available for suramin and Cardiovascular Diseases
| Article | Year |
|---|---|
Chemerin, a novel adipokine in the regulation of angiogenesis.
Topics: Cardiovascular Diseases; Chemokines; DNA; Genetic Variation; Genome-Wide Association Study; Genotype | 2010 |