suramin has been researched along with Cardiomegaly in 1 studies
Suramin: A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.
suramin : A member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years.
Cardiomegaly: Enlargement of the HEART, usually indicated by a cardiothoracic ratio above 0.50. Heart enlargement may involve the right, the left, or both HEART VENTRICLES or HEART ATRIA. Cardiomegaly is a nonspecific symptom seen in patients with chronic systolic heart failure (HEART FAILURE) or several forms of CARDIOMYOPATHIES.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Oda, T | 1 |
| Yamamoto, T | 1 |
| Kato, T | 1 |
| Uchinoumi, H | 1 |
| Fukui, G | 1 |
| Hamada, Y | 1 |
| Nanno, T | 1 |
| Ishiguchi, H | 1 |
| Nakamura, Y | 1 |
| Okamoto, Y | 1 |
| Kono, M | 1 |
| Okuda, S | 1 |
| Kobayashi, S | 1 |
| Bers, DM | 1 |
| Yano, M | 1 |
1 other study available for suramin and Cardiomegaly
| Article | Year |
|---|---|
Nuclear translocation of calmodulin in pathological cardiac hypertrophy originates from ryanodine receptor bound calmodulin.
Topics: Angiotensin II; Animals; Biological Transport; Calmodulin; Cardiomegaly; Cell Nucleus; Cells, Cultur | 2018 |