suramin has been researched along with Cardiac Hypertrophy in 1 studies
Suramin: A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.
suramin : A member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years.
Cardiac Hypertrophy: Enlargement of the HEART due to chamber HYPERTROPHY, an increase in wall thickness without an increase in the number of cells (MYOCYTES, CARDIAC). It is the result of increase in myocyte size, mitochondrial and myofibrillar mass, as well as changes in extracellular matrix.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Oda, T | 1 |
| Yamamoto, T | 1 |
| Kato, T | 1 |
| Uchinoumi, H | 1 |
| Fukui, G | 1 |
| Hamada, Y | 1 |
| Nanno, T | 1 |
| Ishiguchi, H | 1 |
| Nakamura, Y | 1 |
| Okamoto, Y | 1 |
| Kono, M | 1 |
| Okuda, S | 1 |
| Kobayashi, S | 1 |
| Bers, DM | 1 |
| Yano, M | 1 |
1 other study available for suramin and Cardiac Hypertrophy
| Article | Year |
|---|---|
Nuclear translocation of calmodulin in pathological cardiac hypertrophy originates from ryanodine receptor bound calmodulin.
Topics: Angiotensin II; Animals; Biological Transport; Calmodulin; Cardiomegaly; Cell Nucleus; Cells, Cultur | 2018 |