suramin has been researched along with Carcinoma, Epidermoid in 9 studies
Suramin: A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.
suramin : A member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Suramin is a polyanionic agent which has been found to be an effective antineoplastic agent against various human tumors including adrenal, renal and prostatic cancer, and osteosarcoma." | 5.29 | Suramin suppresses hypercalcemia and osteoclastic bone resorption in nude mice bearing a human squamous cancer. ( Boyce, BF; Dunstan, C; Mundy, GR; Rhine, C; Williams, P; Yoneda, T, 1995) |
| "Since human esophageal squamous cell carcinoma expresses abundant epidermal growth factor receptors (EGFR) and proliferates in an autocrine and paracrine manner, it was expected that suramin inhibits tumor growth by disrupting EGFR." | 1.30 | Effect of suramin on human esophageal cancer cells in vitro and in vivo. ( Kamikawa, Y; Naomoto, Y; Orita, K; Shin, R; Tanaka, N, 1997) |
| "Suramin is a polyanionic agent which has been found to be an effective antineoplastic agent against various human tumors including adrenal, renal and prostatic cancer, and osteosarcoma." | 1.29 | Suramin suppresses hypercalcemia and osteoclastic bone resorption in nude mice bearing a human squamous cancer. ( Boyce, BF; Dunstan, C; Mundy, GR; Rhine, C; Williams, P; Yoneda, T, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (11.11) | 18.7374 |
| 1990's | 7 (77.78) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (11.11) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Park, J | 1 |
| Kim, JY | 1 |
| Hwang, SR | 1 |
| Mahmud, F | 1 |
| Byun, Y | 1 |
| Toshkov, A | 1 |
| Trifonov, S | 1 |
| Neĭchev, Kh | 1 |
| Aleksandrov, I | 1 |
| Opŭlchenova, G | 1 |
| Yoneda, T | 1 |
| Williams, P | 1 |
| Rhine, C | 1 |
| Boyce, BF | 1 |
| Dunstan, C | 1 |
| Mundy, GR | 1 |
| Favoni, RE | 1 |
| Ravera, F | 1 |
| Pirani, P | 1 |
| Ardizzoni, A | 1 |
| Noonan, D | 1 |
| de Cupis, A | 1 |
| Li, AT | 1 |
| Lokshin, A | 1 |
| Levitt, ML | 1 |
| Okada, N | 1 |
| Fushimi, M | 1 |
| Nagata, Y | 1 |
| Fukunaga, T | 1 |
| Tsutsumi, Y | 1 |
| Nakagawa, S | 1 |
| Mayumi, T | 1 |
| Shin, R | 1 |
| Naomoto, Y | 1 |
| Kamikawa, Y | 1 |
| Tanaka, N | 1 |
| Orita, K | 1 |
| Weckbecker, G | 1 |
| Liu, R | 1 |
| Tolcsvai, L | 1 |
9 other studies available for suramin and Carcinoma, Epidermoid
| Article | Year |
|---|---|
Chemical Conjugate of Low Molecular Weight Heparin and Suramin Fragment Inhibits Tumor Growth Possibly by Blocking VEGF165.
Topics: Animals; Antineoplastic Agents; Apoptosis; Blotting, Western; Carcinoma, Squamous Cell; Cell Prolife | 2015 |
In vivo effect of naganol on the cytostatic activity of rat peritoneal macrophages.
Topics: Animals; Ascitic Fluid; Carcinoma, Squamous Cell; Corynebacterium Infections; Cytotoxicity, Immunolo | 1981 |
Suramin suppresses hypercalcemia and osteoclastic bone resorption in nude mice bearing a human squamous cancer.
Topics: Adenocarcinoma; Animals; Bone and Bones; Bone Resorption; Calcium; Carcinoma, Squamous Cell; Cell Di | 1995 |
Suramin interferes with auto/paracrine insulin-like growth factor I-controlled proliferative loop on human lung cancer cell lines.
Topics: Adenocarcinoma; Binding, Competitive; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Cell | 1994 |
[Suramin activity in human head and neck squamous cell carcinoma cell lines].
Topics: Antineoplastic Agents; Carcinoma, Squamous Cell; Cell Division; Dose-Response Relationship, Drug; Ep | 1993 |
Effect of suramin on squamous differentiation and apoptosis in three human non-small-cell lung cancer cell lines.
Topics: Adenocarcinoma; Antineoplastic Agents; Apoptosis; Calcimycin; Carcinoma, Adenosquamous; Carcinoma, S | 1996 |
Evaluation of angiogenic inhibitors with an in vivo quantitative angiogenesis method using agarose microencapsulation and mouse hemoglobin enzyme-linked immunosorbent assay.
Topics: Animals; Carcinoma, Squamous Cell; Cortodoxone; Drug Compounding; Drug Evaluation, Preclinical; Enzy | 1996 |
Effect of suramin on human esophageal cancer cells in vitro and in vivo.
Topics: Animals; Antineoplastic Agents; Carcinoma, Squamous Cell; Cell Division; Disease Models, Animal; Dos | 1997 |
Intradermal angiogenesis in nude mice induced by human tumor cells or b-FGF.
Topics: Adenocarcinoma; Animals; Breast Neoplasms; Carcinoma, Squamous Cell; Cell Line; Female; Fibroblast G | 1992 |