suramin has been researched along with Caprine Diseases in 1 studies
Suramin: A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.
suramin : A member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Two other goats appeared to be cured with this dosage of suramin but later developed abnormal central nervous system (CNS) signs and parasitaemia." | 1.28 | Experimental infection of goats with Trypanosoma brucei ssp. and effects of treatment with suramin and Mel-B. ( Chumo, DA; Muriithi, RM; Mwangi, J; Reardon, MJ; Towett, S; Wellde, BT, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Wellde, BT | 1 |
| Reardon, MJ | 1 |
| Chumo, DA | 1 |
| Muriithi, RM | 1 |
| Towett, S | 1 |
| Mwangi, J | 1 |
1 other study available for suramin and Caprine Diseases
| Article | Year |
|---|---|
Experimental infection of goats with Trypanosoma brucei ssp. and effects of treatment with suramin and Mel-B.
Topics: Animals; Arsenicals; Brain; Central Nervous System; Central Nervous System Diseases; Goat Diseases; | 1989 |