suramin has been researched along with Cancer of Nasopharynx in 2 studies
Suramin: A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.
suramin : A member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Suramin was found to have the potential to induce cell cycle arrest in S-phase CNE-2 cells." | 5.38 | Suramin inhibits the growth of nasopharyngeal carcinoma cells via the downregulation of osteopontin. ( Chen, X; Jiang, S; Li, C; Yang, G; Yue, Y; Zhang, T; Zhang, X, 2012) |
| "Suramin was found to have the potential to induce cell cycle arrest in S-phase CNE-2 cells." | 1.38 | Suramin inhibits the growth of nasopharyngeal carcinoma cells via the downregulation of osteopontin. ( Chen, X; Jiang, S; Li, C; Yang, G; Yue, Y; Zhang, T; Zhang, X, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (50.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Jiang, S | 1 |
| Chen, X | 1 |
| Li, C | 1 |
| Zhang, X | 1 |
| Zhang, T | 1 |
| Yue, Y | 1 |
| Yang, G | 1 |
| Chen, JK | 1 |
| Shen, LS | 1 |
| Chao, HH | 1 |
2 other studies available for suramin and Cancer of Nasopharynx
| Article | Year |
|---|---|
Suramin inhibits the growth of nasopharyngeal carcinoma cells via the downregulation of osteopontin.
Topics: Antineoplastic Agents; Apoptosis; Carcinoma; Cell Line, Tumor; Down-Regulation; Humans; Nasopharynge | 2012 |
Correlation of transformation from epithelial to mesenchymal-like morphology and endogenous bFGF levels in human nasopharyngeal carcinoma cells.
Topics: Antibodies; Carcinoma; Epidermal Growth Factor; Epithelial Cells; Fibroblast Growth Factor 2; Fibrob | 1994 |