suramin has been researched along with Cachexia in 2 studies
Suramin: A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.
suramin : A member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years.
Cachexia: General ill health, malnutrition, and weight loss, usually associated with chronic disease.
| Excerpt | Relevance | Reference |
|---|---|---|
| "At present there is no effective treatment for cachexia." | 5.29 | Suramin interferes with interleukin-6 receptor binding in vitro and inhibits colon-26-mediated experimental cancer cachexia in vivo. ( D'Alessandro, F; Fong, M; Freter, CE; Nordan, RP; Strassmann, G; Windsor, S, 1993) |
| "At present there is no effective treatment for cachexia." | 1.29 | Suramin interferes with interleukin-6 receptor binding in vitro and inhibits colon-26-mediated experimental cancer cachexia in vivo. ( D'Alessandro, F; Fong, M; Freter, CE; Nordan, RP; Strassmann, G; Windsor, S, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Strassmann, G | 2 |
| Fong, M | 1 |
| Freter, CE | 1 |
| Windsor, S | 1 |
| D'Alessandro, F | 1 |
| Nordan, RP | 1 |
| Kambayashi, T | 1 |
1 review available for suramin and Cachexia
| Article | Year |
|---|---|
Inhibition of experimental cancer cachexia by anti-cytokine and anti-cytokine-receptor therapy.
Topics: Animals; Antibodies; Cachexia; Cytokines; Humans; Interleukin-6; Mice; Mice, Inbred Strains; Neoplas | 1995 |
1 other study available for suramin and Cachexia
| Article | Year |
|---|---|
Suramin interferes with interleukin-6 receptor binding in vitro and inhibits colon-26-mediated experimental cancer cachexia in vivo.
Topics: Adenocarcinoma; Animals; Cachexia; Colonic Neoplasms; Humans; Interleukin-6; Liver; Male; Mice; Mice | 1993 |