suramin has been researched along with Bruise in 2 studies
Suramin: A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.
suramin : A member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Suramin treatment initiated at 2 weeks post-injury was observed to promote muscle regeneration and muscle strength, and to decrease fibrosis." | 3.78 | Timing of the administration of suramin treatment after muscle injury. ( Fu, FH; Gharaibeh, B; Huard, J; Li, Y; Nozaki, M; Ota, S; Terada, S; Uehara, K, 2012) |
| "Suramin enhances muscle healing by both stimulating muscle regeneration and preventing fibrosis in contused skeletal muscle." | 3.74 | Improved muscle healing after contusion injury by the inhibitory effect of suramin on myostatin, a negative regulator of muscle growth. ( Ambrosio, F; Fu, FH; Huard, J; Li, Y; Nozaki, M; Uehara, K; Zhu, J, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Nozaki, M | 2 |
| Li, Y | 2 |
| Zhu, J | 1 |
| Ambrosio, F | 1 |
| Uehara, K | 2 |
| Fu, FH | 2 |
| Huard, J | 2 |
| Ota, S | 1 |
| Terada, S | 1 |
| Gharaibeh, B | 1 |
2 other studies available for suramin and Bruise
| Article | Year |
|---|---|
Improved muscle healing after contusion injury by the inhibitory effect of suramin on myostatin, a negative regulator of muscle growth.
Topics: Animals; Antineoplastic Agents; Cell Differentiation; Cell Line; Contusions; Down-Regulation; Fibros | 2008 |
Timing of the administration of suramin treatment after muscle injury.
Topics: Animals; Antineoplastic Agents; Contusions; Drug Administration Schedule; Fibroblasts; Fibrosis; Fol | 2012 |