suramin has been researched along with Brill-Symmers Disease in 1 studies
Suramin: A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.
suramin : A member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Suramin was administered at an initial infusion rate of 350 mg/m2/day, which was then modified on the basis of subsequent weekly plasma suramin concentrations in order to reach a final plasma concentrations of 250-350 micrograms/ml." | 2.67 | A pilot study of suramin in the treatment of progressive refractory follicular lymphomas. ( Cooper, MR; Kohler, D; La Rocca, RV; Myers, CE; Stein, CA; Uhrich, M; Weinberger, E, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| La Rocca, RV | 1 |
| Cooper, MR | 1 |
| Stein, CA | 1 |
| Kohler, D | 1 |
| Uhrich, M | 1 |
| Weinberger, E | 1 |
| Myers, CE | 1 |
1 trial available for suramin and Brill-Symmers Disease
| Article | Year |
|---|---|
A pilot study of suramin in the treatment of progressive refractory follicular lymphomas.
Topics: Adult; Humans; Lymphoma, Follicular; Pilot Projects; Suramin | 1992 |