suramin has been researched along with Brain Disorders in 6 studies
Suramin: A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.
suramin : A member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (33.33) | 18.7374 |
| 1990's | 2 (33.33) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (16.67) | 24.3611 |
| 2020's | 1 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Xiang, W | 1 |
| Yang, Z | 1 |
| Xue, H | 1 |
| Wang, J | 2 |
| Niu, F | 1 |
| Chen, C | 1 |
| Wang, Y | 1 |
| Pang, J | 1 |
| Wang, B | 1 |
| Kuepfer, I | 1 |
| Schmid, C | 1 |
| Allan, M | 1 |
| Edielu, A | 1 |
| Haary, EP | 1 |
| Kakembo, A | 1 |
| Kibona, S | 1 |
| Blum, J | 1 |
| Burri, C | 1 |
| GASTAUT, H | 1 |
| ROGER, J | 1 |
| BADIER, M | 1 |
| Jennings, FW | 2 |
| Weir, AB | 1 |
| Agbowu, J | 1 |
| Ajayi, N | 1 |
1 trial available for suramin and Brain Disorders
| Article | Year |
|---|---|
Safety and efficacy of the 10-day melarsoprol schedule for the treatment of second stage Rhodesiense sleeping sickness.
Topics: Adolescent; Adult; Aged; Brain Diseases; Child; Drug Administration Schedule; Endemic Diseases; Fema | 2012 |
5 other studies available for suramin and Brain Disorders
| Article | Year |
|---|---|
P2Y12 receptor-mediated microglia activation involved in delayed encephalopathy after acute carbon monoxide poisoning.
Topics: Animals; Brain Diseases; Carbon Monoxide Poisoning; Hippocampus; Male; Microglia; Purinergic P2Y Rec | 2021 |
[Electroencephalographic manifestations of an old epilepsy and of a recent lesion of the base of the brain in a patient partially deprived of corpus callosum].
Topics: Brain; Brain Diseases; Corpus Callosum; Electroencephalography; Epilepsy; Humans; Suramin | 1951 |
Chemotherapy of CNS-trypanosomiasis: combination chemotherapy with a 5-nitroimidazole (MK 436), an arsenical (Cymelarsan) and suramin.
Topics: Animals; Arsenicals; Brain Diseases; Disease Models, Animal; Drug Therapy, Combination; Female; Mice | 1991 |
Chemotherapy of CNS-trypanosomiasis: the combined use of the arsenicals and nitro-compounds.
Topics: Animals; Antiprotozoal Agents; Arsenicals; Brain Diseases; Drug Synergism; Drug Therapy, Combination | 1991 |
Hyperendemic West African trypanosomiasis in a rural hospital setting.
Topics: Brain Diseases; Dexamethasone; Drug Administration Schedule; Drug Therapy, Combination; Hospitals, R | 1985 |