suramin has been researched along with Bone Loss, Osteoclastic in 4 studies
Suramin: A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.
suramin : A member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Suramin is a polyanionic agent which has been found to be an effective antineoplastic agent against various human tumors including adrenal, renal and prostatic cancer, and osteosarcoma." | 5.29 | Suramin suppresses hypercalcemia and osteoclastic bone resorption in nude mice bearing a human squamous cancer. ( Boyce, BF; Dunstan, C; Mundy, GR; Rhine, C; Williams, P; Yoneda, T, 1995) |
| "Suramin is a polyanionic agent which has been found to be an effective antineoplastic agent against various human tumors including adrenal, renal and prostatic cancer, and osteosarcoma." | 1.29 | Suramin suppresses hypercalcemia and osteoclastic bone resorption in nude mice bearing a human squamous cancer. ( Boyce, BF; Dunstan, C; Mundy, GR; Rhine, C; Williams, P; Yoneda, T, 1995) |
| "Suramin has been shown to have antitumor activity in patients with advanced, hormone refractory prostate cancer." | 1.28 | Suramin inhibits bone resorption and reduces osteoblast number in a neonatal mouse calvarial bone resorption assay. ( Blair, HC; Ewing, MW; Jamai-Dow, C; Kragel, PJ; Linehan, WM; Myers, CE; Schlesinger, PH; Trahan, E; Venzon, D; Walther, MM, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (25.00) | 18.7374 |
| 1990's | 3 (75.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ackerman, NR | 1 |
| Jubb, S | 1 |
| Trimble, B | 1 |
| Marlowe, S | 1 |
| Miram, L | 1 |
| Maloney, P | 1 |
| Yoneda, T | 1 |
| Williams, P | 1 |
| Rhine, C | 1 |
| Boyce, BF | 1 |
| Dunstan, C | 1 |
| Mundy, GR | 1 |
| Farsoudi, KH | 1 |
| Pietschmann, P | 1 |
| Cross, HS | 1 |
| Peterlik, M | 1 |
| Walther, MM | 1 |
| Kragel, PJ | 1 |
| Trahan, E | 1 |
| Venzon, D | 1 |
| Blair, HC | 1 |
| Schlesinger, PH | 1 |
| Jamai-Dow, C | 1 |
| Ewing, MW | 1 |
| Myers, CE | 1 |
| Linehan, WM | 1 |
4 other studies available for suramin and Bone Loss, Osteoclastic
| Article | Year |
|---|---|
Divergent effects of suramin on in vitro and in vivo assays of cartilage degradation.
Topics: Animals; Arthritis, Experimental; Aspartic Acid Endopeptidases; Bone Resorption; Cartilage, Articula | 1983 |
Suramin suppresses hypercalcemia and osteoclastic bone resorption in nude mice bearing a human squamous cancer.
Topics: Adenocarcinoma; Animals; Bone and Bones; Bone Resorption; Calcium; Carcinoma, Squamous Cell; Cell Di | 1995 |
Suramin is a potent inhibitor of calcemic hormone- and growth factor-induced bone resorption in vitro.
Topics: Animals; Bone Resorption; Calcitriol; Cyclic AMP; Dose-Response Relationship, Drug; Epidermal Growth | 1993 |
Suramin inhibits bone resorption and reduces osteoblast number in a neonatal mouse calvarial bone resorption assay.
Topics: Alkaline Phosphatase; Animals; Animals, Newborn; Autoradiography; Bone Resorption; Calcitonin; Calci | 1992 |