suramin has been researched along with Body Weight in 9 studies
Suramin: A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.
suramin : A member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years.
Body Weight: The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Rats treated with the trypanocidal drug suramin, a potent inhibitor of several lysosomal enzymes, develop a storage disorder which mimics the features of mucopolysaccharidosis (Constantopoulos et al." | 7.67 | The suramin-treated rat as a model of mucopolysaccharidosis: reversibility of biochemical and morphological changes in the liver. ( Brady, R; Constantopoulos, G; Rees, S, 1986) |
| "In both rat strains Suramin caused fetal growth retardation, decreased placental blood flow, and increased placental concentration of the isoprostane 8-iso-PGF(2alpha)." | 3.73 | Placental dysfunction in Suramin-treated rats: impact of maternal diabetes and effects of antioxidative treatment. ( Eriksson, UJ; Nash, P; Olovsson, M, 2005) |
| "Rats treated with the trypanocidal drug suramin, a potent inhibitor of several lysosomal enzymes, develop a storage disorder which mimics the features of mucopolysaccharidosis (Constantopoulos et al." | 3.67 | The suramin-treated rat as a model of mucopolysaccharidosis: reversibility of biochemical and morphological changes in the liver. ( Brady, R; Constantopoulos, G; Rees, S, 1986) |
| "In human African trypanosomiasis (HAT), the parasites invade the central nervous system (CNS), leading to the development of meningo-encephalitis and an irreversible demyelinating process, which kills the patient unless specific treatment is undertaken." | 1.32 | Megazol combined with suramin improves a new diagnosis index of the early meningo-encephalitic phase of experimental African trypanosomiasis. ( Bourdon, L; Bouteille, B; Buguet, A; Chevrier, C; Darsaud, A; Dumas, M, 2004) |
| "Chemotherapy for human African trypanosomiasis (HAT), or sleeping sickness, is unreliable because of resistance, refraction and toxic and adverse side-effects." | 1.30 | Megazol combined with suramin: a chemotherapy regimen which reversed the CNS pathology in a model of human African trypanosomiasis in mice. ( Bouteille, B; Chauvière, G; Dumas, M; Enanga, B; Keita, M, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (22.22) | 18.7374 |
| 1990's | 3 (33.33) | 18.2507 |
| 2000's | 4 (44.44) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ballok, DA | 1 |
| Sakic, B | 1 |
| Darsaud, A | 1 |
| Chevrier, C | 1 |
| Bourdon, L | 1 |
| Dumas, M | 2 |
| Buguet, A | 1 |
| Bouteille, B | 2 |
| Song, S | 1 |
| Yu, B | 1 |
| Wei, Y | 1 |
| Wientjes, MG | 1 |
| Au, JL | 1 |
| Nash, P | 1 |
| Olovsson, M | 1 |
| Eriksson, UJ | 1 |
| Payne, RC | 1 |
| Sukanto, IP | 1 |
| Partoutomo, S | 1 |
| Sitepu, P | 1 |
| Jones, TW | 1 |
| Enanga, B | 1 |
| Keita, M | 1 |
| Chauvière, G | 1 |
| Porto, MA | 1 |
| Szende, B | 1 |
| Lapis, K | 1 |
| Jeney, A | 1 |
| Simon, K | 1 |
| Ordög, A | 1 |
| Moldvay, J | 1 |
| Rees, S | 1 |
| Constantopoulos, G | 1 |
| Brady, R | 1 |
9 other studies available for suramin and Body Weight
| Article | Year |
|---|---|
Purine receptor antagonist modulates serology and affective behaviors in lupus-prone mice: evidence of autoimmune-induced pain?
Topics: Analysis of Variance; Animals; Anxiety; Autoantibodies; Autoimmunity; Body Weight; Cell Shape; Dendr | 2008 |
Megazol combined with suramin improves a new diagnosis index of the early meningo-encephalitic phase of experimental African trypanosomiasis.
Topics: Anemia; Animals; Body Weight; Drug Therapy, Combination; Eating; Hematocrit; Male; Meningoencephalit | 2004 |
Low-dose suramin enhanced paclitaxel activity in chemotherapy-naive and paclitaxel-pretreated human breast xenograft tumors.
Topics: Animals; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemother | 2004 |
Placental dysfunction in Suramin-treated rats: impact of maternal diabetes and effects of antioxidative treatment.
Topics: Animals; Antioxidants; Blood Pressure; Body Weight; Diabetes Mellitus, Experimental; Electrolytes; E | 2005 |
Effect of suramin treatment on the productivity of feedlot cattle in a Trypanosoma evansi endemic area of Indonesia.
Topics: Animals; Body Weight; Cattle; Indonesia; Injections, Intravenous; Suramin; Trypanosomiasis, Bovine | 1994 |
Megazol combined with suramin: a chemotherapy regimen which reversed the CNS pathology in a model of human African trypanosomiasis in mice.
Topics: Animals; Body Weight; Central Nervous System Diseases; Disease Models, Animal; Drug Evaluation, Prec | 1998 |
[Preventive measures and treatment of onchocerciasis].
Topics: Administration, Oral; Anthelmintics; Body Weight; Diethylcarbamazine; Dose-Response Relationship, Dr | 1977 |
Liver damaging effect of suramin in normal and carbon-tetrachloride treated rats.
Topics: Animals; Body Weight; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Drug Synergism; | 1991 |
The suramin-treated rat as a model of mucopolysaccharidosis: reversibility of biochemical and morphological changes in the liver.
Topics: Animals; Body Weight; Glycosaminoglycans; Hydrolases; Liver; Lysosomes; Male; Microscopy, Electron; | 1986 |