suramin has been researched along with Blood Poisoning in 6 studies
Suramin: A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.
suramin : A member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Suramin can protect LPS-induced acute lung injury through down-regulation of systemic and pulmonary pro-inflammatory factors, which may be associated with the inhibition of NF-κB activity." | 3.81 | [Inhibitory effect of suramin on inflammatory response in pulmonary tissue and peripheral blood in LPS-induced septic mice]. ( Fang, XM; Han, L; Hou, JC, 2015) |
| "Suramin could inhibit NLRP3/caspase-1/GSDMD canonical pyroptosis pathway in LPS-induced MH-S alveolar macrophages." | 2.44 | RNA-seq revealed the anti-pyroptotic effect of suramin by suppressing NLRP3/caspase-1/GSDMD pathway in LPS-induced MH-S alveolar macrophages. ( Chen, Y; Huang, C; Wang, J; Wang, Z; Zheng, J; Zhou, H; Zhu, Y, 2024) |
| "Urosepsis is a severe condition often caused by Escherichia coli that spontaneously have ascended the urinary tract to the kidneys causing pyelonephritis and potentially bacteraemia." | 1.51 | P2X ( Christensen, MG; Fagerberg, SK; Greve, AS; Johnsen, N; Praetorius, HA; Skals, M, 2019) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 5 (83.33) | 24.3611 |
| 2020's | 1 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Zhu, Y | 1 |
| Wang, Z | 1 |
| Zheng, J | 1 |
| Wang, J | 1 |
| Chen, Y | 2 |
| Huang, C | 1 |
| Zhou, H | 1 |
| Skals, M | 1 |
| Greve, AS | 1 |
| Fagerberg, SK | 1 |
| Johnsen, N | 1 |
| Christensen, MG | 1 |
| Praetorius, HA | 1 |
| Sumi, Y | 1 |
| Woehrle, T | 2 |
| Bao, Y | 3 |
| Li, X | 2 |
| Yao, Y | 1 |
| Inoue, Y | 1 |
| Tanaka, H | 1 |
| Junger, WG | 3 |
| Ledderose, C | 2 |
| Ledderose, S | 1 |
| Heinisch, M | 1 |
| Yip, L | 1 |
| Zhang, J | 2 |
| Robson, SC | 1 |
| Shapiro, NI | 1 |
| Han, L | 1 |
| Hou, JC | 1 |
| Fang, XM | 1 |
| Kondo, Y | 1 |
| Staudenmaier, L | 1 |
| Lee, A | 1 |
6 other studies available for suramin and Blood Poisoning
| Article | Year |
|---|---|
RNA-seq revealed the anti-pyroptotic effect of suramin by suppressing NLRP3/caspase-1/GSDMD pathway in LPS-induced MH-S alveolar macrophages.
Topics: Caspase 1; Humans; Inflammasomes; Interleukin-6; Lipopolysaccharides; Macrophages, Alveolar; NLR Fam | 2024 |
P2X
Topics: Animals; Benzenesulfonates; Blood Platelets; Escherichia coli Infections; Hemolysin Proteins; Male; | 2019 |
Plasma ATP is required for neutrophil activation in a mouse sepsis model.
Topics: Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Animals; Disease Models, Ani | 2014 |
Mitochondrial Dysfunction, Depleted Purinergic Signaling, and Defective T Cell Vigilance and Immune Defense.
Topics: Adolescent; Adult; Calcium Signaling; CD4-Positive T-Lymphocytes; Humans; Jurkat Cells; Mitochondria | 2016 |
[Inhibitory effect of suramin on inflammatory response in pulmonary tissue and peripheral blood in LPS-induced septic mice].
Topics: Acute Lung Injury; Animals; Cell Line; Down-Regulation; Gene Expression Regulation; Inflammation; In | 2015 |
Systemic Adenosine Triphosphate Impairs Neutrophil Chemotaxis and Host Defense in Sepsis.
Topics: Adenosine Triphosphate; Animals; Apyrase; Chemotaxis, Leukocyte; Humans; Mice, Inbred C57BL; Mice, K | 2017 |