suramin has been researched along with Autoimmune Disease in 4 studies
Suramin: A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.
suramin : A member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Suramin treatment was most effective in suppressing EAU when started concurrently with immunization (afferent)." | 5.29 | Suramin treatment suppresses induction of experimental autoimmune uveoretinitis (EAU) in rodents. ( Caspi, RR; Chan, CC; Sartani, G; Silver, PB; Strassmann, G, 1995) |
| "Suramin did not inhibit lipopolysaccharide- or Pam3CSK4-induced IL-6 mRNA expression." | 1.48 | Suramin potently inhibits cGAMP synthase, cGAS, in THP1 cells to modulate IFN-β levels. ( Mikek, C; Opoku-Temeng, C; Sintim, HO; Sooreshjani, MA; Wang, M, 2018) |
| "Suramin treatment was most effective in suppressing EAU when started concurrently with immunization (afferent)." | 1.29 | Suramin treatment suppresses induction of experimental autoimmune uveoretinitis (EAU) in rodents. ( Caspi, RR; Chan, CC; Sartani, G; Silver, PB; Strassmann, G, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (50.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 1 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Wang, M | 1 |
| Sooreshjani, MA | 1 |
| Mikek, C | 1 |
| Opoku-Temeng, C | 1 |
| Sintim, HO | 1 |
| Sartani, G | 1 |
| Silver, PB | 1 |
| Strassmann, G | 1 |
| Chan, CC | 1 |
| Caspi, RR | 1 |
| Novales-Li, P | 1 |
| Shiono, T | 1 |
| Kodama, M | 1 |
| Hanawa, H | 1 |
| Fuse, K | 1 |
| Yamamoto, T | 1 |
| Aizawa, Y | 1 |
4 other studies available for suramin and Autoimmune Disease
| Article | Year |
|---|---|
Suramin potently inhibits cGAMP synthase, cGAS, in THP1 cells to modulate IFN-β levels.
Topics: Anti-Inflammatory Agents; Autoimmune Diseases; Enzyme Inhibitors; Gene Expression Regulation; Humans | 2018 |
Suramin treatment suppresses induction of experimental autoimmune uveoretinitis (EAU) in rodents.
Topics: Animals; Autoimmune Diseases; Eye Proteins; Female; Hypersensitivity, Delayed; Immunization; Immunog | 1995 |
In vitro immunopharmacologic effect of suramin on modifying Th-subset cytokine levels in splenocytes and T-cell clones: a therapeutic application for autoimmune disease.
Topics: Animals; Autoimmune Diseases; Cells, Cultured; Clone Cells; Cytokines; Female; Interferon-gamma; Int | 1996 |
Suppression of myocardial inflammation using suramin, a growth factor blocker.
Topics: Animals; Anti-Inflammatory Agents; Autoimmune Diseases; Cardiomyopathies; Cytokines; Growth Inhibito | 2002 |