suramin has been researched along with Astrocytosis in 3 studies
Suramin: A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.
suramin : A member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Although astrogliosis and glial scar formation have been involved in both damage and repair processes after SCI, their role remains controversial." | 1.38 | Blockade of P2 nucleotide receptors after spinal cord injury reduced the gliotic response and spared tissue. ( Figueroa, JD; Miranda, JD; RodrÃguez-Zayas, AE; Rosas, OR; Santiago, JM; Torrado, AI, 2012) |
| "Suramin-treated animals showed an obvious reduction in several parameters of CNS inflammation: cellular proliferation, GFAP levels, and tenascin-C immunoreactivity were reduced in suramin-treated as compared to control animals at early time points." | 1.30 | Suramin disrupts the gliotic response following a stab wound injury to the adult rat brain. ( Di Prospero, NA; Geller, HM; Ho, SY; McAuliffe, WG; Meiners, S; Zhou, XR, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (33.33) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kim, JE | 1 |
| Kwak, SE | 1 |
| Jo, SM | 1 |
| Kang, TC | 1 |
| RodrÃguez-Zayas, AE | 1 |
| Torrado, AI | 1 |
| Rosas, OR | 1 |
| Santiago, JM | 1 |
| Figueroa, JD | 1 |
| Miranda, JD | 1 |
| Di Prospero, NA | 1 |
| Zhou, XR | 1 |
| Meiners, S | 1 |
| McAuliffe, WG | 1 |
| Ho, SY | 1 |
| Geller, HM | 1 |
3 other studies available for suramin and Astrocytosis
| Article | Year |
|---|---|
Blockade of P2X receptor prevents astroglial death in the dentate gyrus following pilocarpine-induced status epilepticus.
Topics: Animals; Antineoplastic Agents; Astrocytes; Cell Death; Cell Shape; Convulsants; Dentate Gyrus; Dise | 2009 |
Blockade of P2 nucleotide receptors after spinal cord injury reduced the gliotic response and spared tissue.
Topics: Animals; Antineoplastic Agents; Astrocytes; Behavior, Animal; Female; Glial Fibrillary Acidic Protei | 2012 |
Suramin disrupts the gliotic response following a stab wound injury to the adult rat brain.
Topics: Animals; Antineoplastic Agents; Astrocytes; Brain Injuries; Calcium-Binding Proteins; Cell Division; | 1998 |