suramin has been researched along with Arteriosclerosis in 6 studies
Suramin: A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.
suramin : A member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years.
Arteriosclerosis: Thickening and loss of elasticity of the walls of ARTERIES of all sizes. There are many forms classified by the types of lesions and arteries involved, such as ATHEROSCLEROSIS with fatty lesions in the ARTERIAL INTIMA of medium and large muscular arteries.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We described a mouse model of venous bypass graft arteriosclerosis that can be effectively retarded by locally applied suramin, a growth factor receptor antagonist." | 7.70 | Inhibition of neointima hyperplasia of mouse vein grafts by locally applied suramin. ( Dietrich, H; Hu, Y; Wick, G; Xu, Q; Zou, Y, 1999) |
| "We described a mouse model of venous bypass graft arteriosclerosis that can be effectively retarded by locally applied suramin, a growth factor receptor antagonist." | 3.70 | Inhibition of neointima hyperplasia of mouse vein grafts by locally applied suramin. ( Dietrich, H; Hu, Y; Wick, G; Xu, Q; Zou, Y, 1999) |
| "Suramin has an inhibitory effect on the neointimal thickening and intimal smooth muscle cell proliferation after intimal injury in the rabbit aorta, but has no effect on platelet function." | 1.29 | Suramin inhibits intimal thickening following intimal injury in the rabbit aorta in vivo. ( Asada, Y; Marutsuka, K; Sumiyoshi, A; Tsuneyoshi, A, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 6 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ragazzi, E | 1 |
| Chinellato, A | 1 |
| Pandolfo, L | 1 |
| Froldi, G | 1 |
| Caparrotta, L | 1 |
| Aliev, G | 1 |
| Prosdocimi, M | 1 |
| Fassina, G | 1 |
| Sumiyoshi, A | 2 |
| Asada, Y | 2 |
| Marutsuka, K | 2 |
| Hayashi, T | 1 |
| Kisanuki, A | 1 |
| Tsuneyoshi, A | 2 |
| Sato, Y | 1 |
| Rasheed, Q | 1 |
| Cacchione, JG | 1 |
| Berry, J | 1 |
| Richards, F | 1 |
| Bryant, L | 1 |
| Strony, J | 1 |
| Enger, C | 1 |
| Hodgson, JM | 1 |
| Cullen, P | 1 |
| Cignarella, A | 1 |
| Brennhausen, B | 1 |
| Mohr, S | 1 |
| Assmann, G | 1 |
| von Eckardstein, A | 1 |
| Hu, Y | 1 |
| Zou, Y | 1 |
| Dietrich, H | 1 |
| Wick, G | 1 |
| Xu, Q | 1 |
1 review available for suramin and Arteriosclerosis
| Article | Year |
|---|---|
Platelets and intimal thickening.
Topics: Animals; Arteriosclerosis; Blood Platelets; Epoprostenol; Imidazoles; Male; Muscle, Smooth, Vascular | 1995 |
5 other studies available for suramin and Arteriosclerosis
| Article | Year |
|---|---|
Endothelial nucleotide-mediated aorta relaxation in aged Watanabe heritable hyperlipidemic rabbits.
Topics: Acetylcholine; Adenosine Triphosphate; Aging; Animals; Aorta, Thoracic; Arginine; Arteriosclerosis; | 1995 |
Suramin inhibits intimal thickening following intimal injury in the rabbit aorta in vivo.
Topics: Animals; Aorta; Arteriosclerosis; Cell Division; Depression, Chemical; Male; Microscopy, Electron, S | 1994 |
Local intramural drug delivery using an infusion balloon following angioplasty in normal and atherosclerotic vessels.
Topics: Angioplasty, Balloon, Coronary; Animals; Arteriosclerosis; Catheterization; Coronary Artery Disease; | 1994 |
Phenotype-dependent differences in apolipoprotein E metabolism and in cholesterol homeostasis in human monocyte-derived macrophages.
Topics: Adult; Alzheimer Disease; Apolipoproteins E; Arteriosclerosis; Cholesterol; Cholesterol Esters; Fema | 1998 |
Inhibition of neointima hyperplasia of mouse vein grafts by locally applied suramin.
Topics: Animals; Arteriosclerosis; Carotid Arteries; Cell Movement; Enzyme Activation; Hyperplasia; Immunohi | 1999 |