Page last updated: 2024-11-04

suramin and Anoxemia

suramin has been researched along with Anoxemia in 11 studies

Suramin: A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.
suramin : A member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years.

Research Excerpts

ExcerptRelevanceReference
"In this study the effect of suramin on tumor growth, vascularity and oxygenation of a human glioma xenografted in the nude mouse was examined."7.70Suramin treatment of human glioma xenografts; effects on tumor vasculature and oxygenation status. ( Bakker, JH; Bernsen, HJ; Boerman, RH; Peters, JP; Rijken, PF; van der Kogel, AJ; Wesseling, P, 1999)
" The nicotinic blocker mecamylamine (50 microM) ablated the excitatory actions of exogenous ACh and increased, rather than decreased, AP activity during moderate hypoxia."3.75Nicotinic acetylcholine receptors do not mediate excitatory transmission in young rat carotid body. ( Donnelly, DF, 2009)
"In this study the effect of suramin on tumor growth, vascularity and oxygenation of a human glioma xenografted in the nude mouse was examined."3.70Suramin treatment of human glioma xenografts; effects on tumor vasculature and oxygenation status. ( Bakker, JH; Bernsen, HJ; Boerman, RH; Peters, JP; Rijken, PF; van der Kogel, AJ; Wesseling, P, 1999)

Research

Studies (11)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (18.18)18.2507
2000's6 (54.55)29.6817
2010's2 (18.18)24.3611
2020's1 (9.09)2.80

Authors

AuthorsStudies
Vandorpe, DH1
Rivera, A1
Ganter, M1
Dankwa, S1
Wohlgemuth, JG1
Dlott, JS1
Snyder, LM1
Brugnara, C1
Duraisingh, M1
Alper, SL1
Rahbar, S1
Pan, W1
Jonz, MG1
Visovatti, SH1
Hyman, MC1
Goonewardena, SN1
Anyanwu, AC1
Kanthi, Y1
Robichaud, P1
Wang, J1
Petrovic-Djergovic, D1
Rattan, R1
Burant, CF1
Pinsky, DJ1
Baek, EB1
Yoo, HY1
Park, SJ1
Kim, HS1
Kim, SD1
Earm, YE1
Kim, SJ1
Meng, F1
To, WK1
Gu, Y1
Donnelly, DF1
Mokashi, A1
Li, J1
Roy, A1
Baby, SM1
Lahiri, S1
Bell, HJ1
Inoue, T1
Shum, K1
Luk, C1
Syed, NI1
Bernsen, HJ1
Rijken, PF1
Peters, JP1
Bakker, JH1
Boerman, RH1
Wesseling, P1
van der Kogel, AJ1
Pessina, F1
Matteucci, G1
Esposito, L1
Gorelli, B1
Valoti, M1
Sgaragli, G1
Leith, JT1
Papa, G1
Quaranto, L1
Michelson, S1

Other Studies

11 other studies available for suramin and Anoxemia

ArticleYear
Purinergic signaling is essential for full Psickle activation by hypoxia and by normoxic acid pH in mature human sickle red cells and in vitro-differentiated cultured human sickle reticulocytes.
    Pflugers Archiv : European journal of physiology, 2022, Volume: 474, Issue:5

    Topics: Adenosine Triphosphate; Anemia, Sickle Cell; Apyrase; Cations; Cells, Cultured; Erythrocytes; Humans

2022
Purinergic and Cholinergic Drugs Mediate Hyperventilation in Zebrafish: Evidence from a Novel Chemical Screen.
    PloS one, 2016, Volume: 11, Issue:4

    Topics: Animals; Atropine; Cholinergic Agents; Female; Gills; Hyperventilation; Hypoxia; Immunohistochemistr

2016
Purinergic dysregulation in pulmonary hypertension.
    American journal of physiology. Heart and circulatory physiology, 2016, 07-01, Volume: 311, Issue:1

    Topics: Adenosine; Adenosine Triphosphate; Animals; Antigens, CD; Antihypertensive Agents; Apyrase; Arterial

2016
Luminal ATP-induced contraction of rabbit pulmonary arteries and role of purinoceptors in the regulation of pulmonary arterial pressure.
    Pflugers Archiv : European journal of physiology, 2008, Volume: 457, Issue:2

    Topics: Adenosine Triphosphate; Animals; Blood Pressure; Calcium Signaling; Coronary Circulation; Coronary V

2008
Role of TRP channels and NCX in mediating hypoxia-induced [Ca(2+)](i) elevation in PC12 cells.
    Respiratory physiology & neurobiology, 2008, Dec-31, Volume: 164, Issue:3

    Topics: Animals; Boron Compounds; Calcium; Calcium Channel Blockers; Dose-Response Relationship, Drug; Gene

2008
Nicotinic acetylcholine receptors do not mediate excitatory transmission in young rat carotid body.
    Journal of applied physiology (Bethesda, Md. : 1985), 2009, Volume: 107, Issue:6

    Topics: Acetylcholine; Action Potentials; Analysis of Variance; Animals; Carotid Body; Chemoreceptor Cells;

2009
ATP causes glomus cell [Ca2+]c increase without corresponding increases in CSN activity.
    Respiratory physiology & neurobiology, 2003, Oct-16, Volume: 138, Issue:1

    Topics: Adenosine Triphosphate; Afferent Pathways; Animals; Brain Stem; Calcium Signaling; Carotid Body; Car

2003
Peripheral oxygen-sensing cells directly modulate the output of an identified respiratory central pattern generating neuron.
    The European journal of neuroscience, 2007, Volume: 25, Issue:12

    Topics: Action Potentials; Animals; Antinematodal Agents; Behavior, Animal; Brain; Dose-Response Relationshi

2007
Suramin treatment of human glioma xenografts; effects on tumor vasculature and oxygenation status.
    Journal of neuro-oncology, 1999, Volume: 44, Issue:2

    Topics: Animals; Antineoplastic Agents; Blood Vessels; Brain Neoplasms; Glioma; Humans; Hypoxia; Mice; Mice,

1999
Protection of intrinsic nerves of guinea-pig detrusor strips against anoxia/glucopenia and reperfusion injury by taurine.
    Advances in experimental medicine and biology, 2000, Volume: 483

    Topics: Aminoethylphosphonic Acid; Animals; Atropine; Electric Stimulation; Evoked Potentials; Glucose; Guin

2000
Modification of the volumetric growth responses and steady-state hypoxic fractions of xenografted DLD-2 human colon carcinomas by administration of basic fibroblast growth factor or suramin.
    British journal of cancer, 1992, Volume: 66, Issue:2

    Topics: Adenocarcinoma; Animals; Cell Division; Cell Line; Cell Survival; Colonic Neoplasms; Dose-Response R

1992