suramin has been researched along with Alzheimer Disease in 6 studies
Suramin: A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.
suramin : A member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years.
Alzheimer Disease: A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (16.67) | 18.2507 |
| 2000's | 3 (50.00) | 29.6817 |
| 2010's | 1 (16.67) | 24.3611 |
| 2020's | 1 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Prince, PR | 1 |
| Hochmair, J | 1 |
| Brognaro, H | 1 |
| Gevorgyan, S | 1 |
| Franck, M | 1 |
| Schubert, R | 1 |
| Lorenzen, K | 1 |
| Yazici, S | 1 |
| Mandelkow, E | 1 |
| Wegmann, S | 1 |
| Betzel, C | 1 |
| Colombo, R | 1 |
| Carotti, A | 1 |
| Catto, M | 1 |
| Racchi, M | 1 |
| Lanni, C | 1 |
| Verga, L | 1 |
| Caccialanza, G | 1 |
| De Lorenzi, E | 1 |
| León-Otegui, M | 1 |
| Gómez-Villafuertes, R | 1 |
| Díaz-Hernández, JI | 1 |
| Díaz-Hernández, M | 1 |
| Miras-Portugal, MT | 1 |
| Gualix, J | 1 |
| Haughey, NJ | 1 |
| Mattson, MP | 1 |
| Cullen, P | 1 |
| Cignarella, A | 1 |
| Brennhausen, B | 1 |
| Mohr, S | 1 |
| Assmann, G | 1 |
| von Eckardstein, A | 1 |
| Exley, C | 1 |
| Korchazhkina, OV | 1 |
6 other studies available for suramin and Alzheimer Disease
| Article | Year |
|---|---|
Initiation and modulation of Tau protein phase separation by the drug suramin.
Topics: Alzheimer Disease; Heparin; Humans; RNA; Suramin; tau Proteins | 2023 |
CE can identify small molecules that selectively target soluble oligomers of amyloid beta protein and display antifibrillogenic activity.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Cell Line, Tumor; Cell Survival; Electroph | 2009 |
Opposite effects of P2X7 and P2Y2 nucleotide receptors on α-secretase-dependent APP processing in Neuro-2a cells.
Topics: Adenosine Triphosphate; Affinity Labels; Alzheimer Disease; Amyloid beta-Protein Precursor; Amyloid | 2011 |
Alzheimer's amyloid beta-peptide enhances ATP/gap junction-mediated calcium-wave propagation in astrocytes.
Topics: Adenosine Triphosphate; Alzheimer Disease; Amyloid beta-Peptides; Animals; Animals, Newborn; Astrocy | 2003 |
Phenotype-dependent differences in apolipoprotein E metabolism and in cholesterol homeostasis in human monocyte-derived macrophages.
Topics: Adult; Alzheimer Disease; Apolipoproteins E; Arteriosclerosis; Cholesterol; Cholesterol Esters; Fema | 1998 |
Promotion of formation of amyloid fibrils by aluminium adenosine triphosphate (AlATP).
Topics: Adenosine; Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Benzothiazoles; Fluorescent Dyes; Huma | 2001 |