suramin has been researched along with Alloxan Diabetes in 6 studies
Suramin: A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.
suramin : A member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In both rat strains Suramin caused fetal growth retardation, decreased placental blood flow, and increased placental concentration of the isoprostane 8-iso-PGF(2alpha)." | 3.73 | Placental dysfunction in Suramin-treated rats: impact of maternal diabetes and effects of antioxidative treatment. ( Eriksson, UJ; Nash, P; Olovsson, M, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (16.67) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (16.67) | 29.6817 |
| 2010's | 1 (16.67) | 24.3611 |
| 2020's | 3 (50.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chyła-Danił, G | 1 |
| Sałaga-Zaleska, K | 3 |
| Kreft, E | 2 |
| Stumski, O | 1 |
| Krzesińska, A | 1 |
| Sakowicz-Burkiewicz, M | 1 |
| Kuchta, A | 3 |
| Jankowski, M | 3 |
| Chyła, G | 2 |
| Dąbkowski, K | 2 |
| Pikul, P | 1 |
| Herman, S | 1 |
| Lenartowicz, M | 1 |
| Korrapati, MC | 1 |
| Shaner, BE | 1 |
| Neely, BA | 1 |
| Alge, JL | 1 |
| Arthur, JM | 1 |
| Schnellmann, RG | 1 |
| NORBERG, B | 1 |
| Nash, P | 1 |
| Olovsson, M | 1 |
| Eriksson, UJ | 1 |
6 other studies available for suramin and Alloxan Diabetes
| Article | Year |
|---|---|
Long-Term Effects of Suramin on Renal Function in Streptozotocin-Induced Diabetes in Rats.
Topics: Acetylcholine; Albumins; Animals; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Kidney; N | 2023 |
Suramin enhances the urinary excretion of VEGF-A in normoglycemic and streptozotocin-induced diabetic rats.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Kidney; Male; Matri | 2021 |
Effect of suramin on urinary excretion of diabetes-induced glomerular and tubular injury parameters in rats.
Topics: Animals; Biomarkers; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Kidney Glomerulus; Mal | 2021 |
Diabetes-induced renal injury in rats is attenuated by suramin.
Topics: Animals; Biomarkers; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Intercellular Adhesion | 2012 |
Alkaline liver phosphatases in regenerating rat liver; influence of alloxan diabetes, insulin and Bayer 205.
Topics: Alkaline Phosphatase; Animals; Diabetes Mellitus, Experimental; Insulin; Leadership; Liver; Phosphor | 1952 |
Placental dysfunction in Suramin-treated rats: impact of maternal diabetes and effects of antioxidative treatment.
Topics: Animals; Antioxidants; Blood Pressure; Body Weight; Diabetes Mellitus, Experimental; Electrolytes; E | 2005 |