suramin has been researched along with Allergic Encephalomyelitis in 2 studies
Suramin: A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.
suramin : A member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The present study sought to examine the immunopharmacologic effects of suramin on splenocytes from experimental allergic encephalomyelitis (EAE)-induced mice, taken in line with a previous observed action of suramin in ameliorating EAE." | 7.69 | Suramin exerts in vivo cytokine modulatory properties on splenocytes from experimental allergic encephalomyelitis-induced SJL mice: implications for autoimmune disease therapy. ( Novales-Li, P, 1996) |
| "Suramin was tested for its ability to suppress experimental allergic encephalomyelitis." | 7.67 | Suppression of the development of experimental allergic encephalomyelitis by suramin. ( Asghar, SS; Hommes, OR; Uitdehaag, BM; van der Helm, HJ; van der Veen, RC, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (50.00) | 18.7374 |
| 1990's | 1 (50.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Novales-Li, P | 1 |
| van der Veen, RC | 1 |
| Asghar, SS | 1 |
| Uitdehaag, BM | 1 |
| van der Helm, HJ | 1 |
| Hommes, OR | 1 |
2 other studies available for suramin and Allergic Encephalomyelitis
| Article | Year |
|---|---|
Suramin exerts in vivo cytokine modulatory properties on splenocytes from experimental allergic encephalomyelitis-induced SJL mice: implications for autoimmune disease therapy.
Topics: Animals; Cytokines; Encephalomyelitis, Autoimmune, Experimental; Female; Interferon-gamma; Interleuk | 1996 |
Suppression of the development of experimental allergic encephalomyelitis by suramin.
Topics: Animals; Encephalomyelitis, Autoimmune, Experimental; Immunization; Male; Mycobacterium tuberculosis | 1985 |