suramin has been researched along with Adrenal Cortex Neoplasms in 10 studies
Suramin: A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.
suramin : A member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years.
Adrenal Cortex Neoplasms: Tumors or cancers of the ADRENAL CORTEX.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The efficacy of mitotane in providing objective tumour responses in patients with adrenocortical carcinoma (ACC), has been recently questioned." | 6.17 | Cytotoxic chemotherapy for adrenocortical carcinoma. ( Alì, A; Angeli, A; Berruti, A; Dogliotti, L; Paccotti, P; Pia, A, 1995) |
| "Treatment with suramin (Germanin) was begun in August 1987." | 5.28 | [Treatment of metastatic adrenal carcinoma with suramin]. ( Allolio, B; Arlt, W; Jaursch-Hancke, C; Metzler, U; Reincke, M; Winkelmann, W, 1989) |
| "(1) Suramin is of antineoplastic efficacy in the treatment of metastatic adrenocortical carcinoma." | 3.69 | Suramin in adrenocortical cancer: limited efficacy and serious toxicity. ( Allolio, B; Arlt, W; Reincke, M; Siekmann, L; Winkelmann, W, 1994) |
| "Treatment with suramin (Germanin) was begun in August 1987." | 1.28 | [Treatment of metastatic adrenal carcinoma with suramin]. ( Allolio, B; Arlt, W; Jaursch-Hancke, C; Metzler, U; Reincke, M; Winkelmann, W, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (30.00) | 18.7374 |
| 1990's | 6 (60.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (10.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Costa, R | 1 |
| Wesolowski, R | 1 |
| Raghavan, D | 1 |
| Dogliotti, L | 1 |
| Berruti, A | 1 |
| Pia, A | 1 |
| Paccotti, P | 1 |
| Alì, A | 1 |
| Angeli, A | 1 |
| Arlt, W | 3 |
| Reincke, M | 3 |
| Siekmann, L | 2 |
| Winkelmann, W | 3 |
| Allolio, B | 4 |
| Höfle, G | 1 |
| Gasser, RW | 1 |
| Lhotta, K | 1 |
| Janetschek, G | 1 |
| Kreczy, A | 1 |
| Finkenstedt, G | 1 |
| May, E | 1 |
| Wellstein, A | 1 |
| Lupu, R | 1 |
| Zugmaier, G | 1 |
| Flamm, SL | 1 |
| Cheville, AL | 1 |
| Delli Bovi, P | 1 |
| Basilico, C | 1 |
| Lippman, ME | 1 |
| Kern, FG | 1 |
| La Rocca, RV | 1 |
| Stein, CA | 2 |
| Danesi, R | 1 |
| Jamis-Dow, CA | 1 |
| Weiss, GH | 1 |
| Myers, CE | 2 |
| Deuss, U | 1 |
| Jaursch-Hancke, C | 1 |
| Metzler, U | 1 |
| LaRocca, RV | 1 |
| Thomas, R | 1 |
| McAtee, N | 1 |
2 reviews available for suramin and Adrenal Cortex Neoplasms
| Article | Year |
|---|---|
Chemotherapy for advanced adrenal cancer: improvement from a molecular approach?
Topics: Adrenal Cortex Neoplasms; Adrenocortical Carcinoma; Antineoplastic Agents; Antineoplastic Combined C | 2011 |
Cytotoxic chemotherapy for adrenocortical carcinoma.
Topics: Adolescent; Adrenal Cortex Neoplasms; Adult; Animals; Antineoplastic Combined Chemotherapy Protocols | 1995 |
1 trial available for suramin and Adrenal Cortex Neoplasms
| Article | Year |
|---|---|
Cytotoxic chemotherapy for adrenocortical carcinoma.
Topics: Adolescent; Adrenal Cortex Neoplasms; Adult; Animals; Antineoplastic Combined Chemotherapy Protocols | 1995 |
8 other studies available for suramin and Adrenal Cortex Neoplasms
| Article | Year |
|---|---|
Suramin in adrenocortical cancer: limited efficacy and serious toxicity.
Topics: Adrenal Cortex Neoplasms; Adult; Aged; Blood Coagulation; Bone Marrow; Carcinoma; Drug Eruptions; Fe | 1994 |
Adrenocortical carcinoma evolving after diagnosis of preclinical Cushing's syndrome in an adrenal incidentaloma. A case report.
Topics: Adrenal Cortex Neoplasms; Adrenalectomy; Adult; Androgens; Antineoplastic Combined Chemotherapy Prot | 1998 |
Fatal toxic epidermal necrolysis during suramin therapy.
Topics: Adrenal Cortex Neoplasms; Female; Humans; Middle Aged; Stevens-Johnson Syndrome; Suramin | 1991 |
Autocrine growth stimulation by secreted Kaposi fibroblast growth factor but not by endogenous basic fibroblast growth factor.
Topics: Adenocarcinoma; Adrenal Cortex Neoplasms; Animals; Down-Regulation; Fibroblast Growth Factor 2; Fibr | 1990 |
Suramin in adrenal cancer: modulation of steroid hormone production, cytotoxicity in vitro, and clinical antitumor effect.
Topics: Adrenal Cortex Neoplasms; Adrenal Glands; Adult; Aged; Animals; Antineoplastic Agents; Cell Line; Fe | 1990 |
Suramin for treatment of adrenocortical carcinoma.
Topics: Adrenal Cortex Neoplasms; Adult; Carcinoma; Female; Humans; Male; Middle Aged; Suramin | 1989 |
[Treatment of metastatic adrenal carcinoma with suramin].
Topics: Adrenal Cortex Neoplasms; Antineoplastic Combined Chemotherapy Protocols; Carcinoma; Combined Modali | 1989 |
Suramin: an anticancer drug with a unique mechanism of action.
Topics: Adenocarcinoma; Adrenal Cortex Neoplasms; Adult; Antineoplastic Agents; Carcinoma; Female; Humans; K | 1989 |