suramin has been researched along with Adrenal Cortex Diseases in 2 studies
Suramin: A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.
suramin : A member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years.
Adrenal Cortex Diseases: Pathological processes of the ADRENAL CORTEX.
| Excerpt | Relevance | Reference |
|---|---|---|
| " There appeared to be a cumulative dose-response relationship to the development of glucocorticoid insufficiency, with no instances being observed at doses < 4." | 2.68 | Mineralocorticoid insufficiency due to suramin therapy. ( Janisch, L; Kobayashi, K; Ratain, MJ; Vogelzang, NJ; Vokes, EE; Weiss, RE, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (50.00) | 18.7374 |
| 1990's | 1 (50.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kobayashi, K | 1 |
| Weiss, RE | 1 |
| Vogelzang, NJ | 1 |
| Vokes, EE | 1 |
| Janisch, L | 1 |
| Ratain, MJ | 1 |
| Stein, CA | 1 |
| Saville, W | 1 |
| Yarchoan, R | 1 |
| Broder, S | 1 |
| Gelmann, EP | 1 |
1 trial available for suramin and Adrenal Cortex Diseases
| Article | Year |
|---|---|
Mineralocorticoid insufficiency due to suramin therapy.
Topics: Addison Disease; Adrenal Cortex Diseases; Adrenocorticotropic Hormone; Aged; Aldosterone; Antineopla | 1996 |
1 other study available for suramin and Adrenal Cortex Diseases
| Article | Year |
|---|---|
Suramin and function of the adrenal cortex.
Topics: Acquired Immunodeficiency Syndrome; Adrenal Cortex Diseases; Adult; Humans; Male; Suramin | 1986 |