suramin has been researched along with Adrenal Cancer in 12 studies
Suramin: A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.
suramin : A member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Human pheochromocytoma and PC12 rat pheochromocytoma cells were grown in medium supplemented with suramin at concentrations of 1-1,000 micrograms/ml (1." | 7.69 | Antiproliferative effect of suramin on primary cultures of human pheochromocytomas and rat PC12 pheochromocytoma cells. ( Clark, OH; Duh, QY; Rothmund, M; Siperstein, AE; Wong, MG; Zielke, A, 1997) |
| "The effect of suramin on testosterone production was evaluated in cancer patients, adult male rats, rat Leydig cells, and NCI-H295 human adrenal cancer cells." | 3.69 | Clinical and experimental evidence of inhibition of testosterone production by suramin. ( Cooper, MR; Danesi, R; Del Tacca, M; Kragel, PJ; La Rocca, RV; Myers, CE; Paparelli, A; Pellegrini, A; Ricciardi, MP; Soldani, P, 1996) |
| "Human pheochromocytoma and PC12 rat pheochromocytoma cells were grown in medium supplemented with suramin at concentrations of 1-1,000 micrograms/ml (1." | 3.69 | Antiproliferative effect of suramin on primary cultures of human pheochromocytomas and rat PC12 pheochromocytoma cells. ( Clark, OH; Duh, QY; Rothmund, M; Siperstein, AE; Wong, MG; Zielke, A, 1997) |
| "Vortex keratopathy occurred in six patients given high-dose intravenous suramin for adrenocortical carcinoma." | 3.67 | Suramin keratopathy. ( Chan, CC; Holland, EJ; Kuwabara, T; LaRocca, R; McAtee, N; Myers, CE; Nussenblatt, RN; Palestine, AG; Stein, CA; Thomas, R, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (16.67) | 18.7374 |
| 1990's | 10 (83.33) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Koizumi, S | 1 |
| Nakazawa, K | 3 |
| Inoue, K | 3 |
| Danesi, R | 2 |
| La Rocca, RV | 3 |
| Cooper, MR | 2 |
| Ricciardi, MP | 1 |
| Pellegrini, A | 1 |
| Soldani, P | 1 |
| Kragel, PJ | 1 |
| Paparelli, A | 1 |
| Del Tacca, M | 1 |
| Myers, CE | 4 |
| Zielke, A | 1 |
| Wong, MG | 1 |
| Siperstein, AE | 1 |
| Clark, OH | 1 |
| Rothmund, M | 1 |
| Duh, QY | 1 |
| Lieberman, R | 1 |
| Gernt, PR | 1 |
| Weinberger, MS | 1 |
| Headlee, DJ | 1 |
| Kohler, DR | 1 |
| Goldspiel, BR | 1 |
| Peck, CC | 1 |
| Wellstein, A | 1 |
| Zugmaier, G | 1 |
| Califano, JA | 1 |
| Kern, F | 1 |
| Paik, S | 1 |
| Lippman, ME | 1 |
| Fujimori, K | 2 |
| Takanaka, A | 2 |
| Baldus, M | 1 |
| Allolio, B | 1 |
| Brass, H | 1 |
| Schwartz, RW | 1 |
| Sloan, DA | 1 |
| Kenady, DE | 1 |
| Stein, CA | 2 |
| Vierhapper, H | 1 |
| Mostbeck, G | 1 |
| Waldhäusl, W | 1 |
| Holland, EJ | 1 |
| Palestine, AG | 1 |
| LaRocca, R | 1 |
| Chan, CC | 1 |
| Kuwabara, T | 1 |
| Thomas, R | 1 |
| McAtee, N | 1 |
| Nussenblatt, RN | 1 |
2 reviews available for suramin and Adrenal Cancer
| Article | Year |
|---|---|
Diagnosis and treatment of primary adrenal tumors.
Topics: Adenoma; Adrenal Gland Neoplasms; Adrenalectomy; Adult; Aged; Carcinoma; Cushing Syndrome; Diagnosis | 1991 |
Suramin, a novel antitumor compound.
Topics: Adrenal Gland Neoplasms; Antineoplastic Agents; Humans; Lymphoma; Suramin; Tumor Cells, Cultured | 1990 |
1 trial available for suramin and Adrenal Cancer
| Article | Year |
|---|---|
Adaptive control with feedback strategies for suramin dosing.
Topics: Adrenal Gland Neoplasms; Antineoplastic Agents; Bayes Theorem; Creatinine; Drug Monitoring; Humans; | 1992 |
9 other studies available for suramin and Adrenal Cancer
| Article | Year |
|---|---|
Inhibition by Zn2+ of uridine 5'-triphosphate-induced Ca(2+)-influx but not Ca(2+)-mobilization in rat phaeochromocytoma cells.
Topics: Adenosine Triphosphate; Adrenal Gland Neoplasms; Animals; Calcium; Cells, Cultured; Dopamine; Dose-R | 1995 |
Clinical and experimental evidence of inhibition of testosterone production by suramin.
Topics: 3-Hydroxysteroid Dehydrogenases; Adrenal Gland Neoplasms; Adult; Aged; Animals; Follicle Stimulating | 1996 |
Antiproliferative effect of suramin on primary cultures of human pheochromocytomas and rat PC12 pheochromocytoma cells.
Topics: Adrenal Gland Neoplasms; Animals; Antineoplastic Agents; Cell Division; Cell Survival; Drug Screenin | 1997 |
Tumor growth dependent on Kaposi's sarcoma-derived fibroblast growth factor inhibited by pentosan polysulfate.
Topics: Adrenal Gland Neoplasms; Animals; Breast Neoplasms; Cell Division; Endothelium, Vascular; Female; Fi | 1991 |
Effects of ATP antagonists on purinoceptor-operated inward currents in rat phaeochromocytoma cells.
Topics: Adenosine Triphosphate; Adrenal Gland Neoplasms; Animals; Electric Conductivity; Ion Channels; Kinet | 1991 |
[Suramin--a new therapeutic principle in the treatment of metastatic adrenal gland cancer].
Topics: Adenoma; Adrenal Gland Neoplasms; Blood Coagulation Tests; Combined Modality Therapy; Drug Administr | 1990 |
Reversible and selective antagonism by suramin of ATP-activated inward current in PC12 phaeochromocytoma cells.
Topics: Adenosine Triphosphate; Adrenal Gland Neoplasms; Animals; Cell Membrane; Methacholine Compounds; Nic | 1990 |
Effect of suramin in a patient with adrenocortical carcinoma.
Topics: Adrenal Gland Neoplasms; Adult; Carcinoma; Drug Therapy, Combination; Humans; Male; Mitotane; Surami | 1989 |
Suramin keratopathy.
Topics: Adrenal Cortex; Adrenal Gland Neoplasms; Adult; Carcinoma; Corneal Diseases; Female; Humans; Injecti | 1988 |