suramin has been researched along with Adjuvant Arthritis in 4 studies
Suramin: A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.
suramin : A member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In order to determine if the endogenous opioid system is involved in this antinociception, naloxone was administered just prior to the injection of a selective P2X3/P2X2/3 receptor antagonist, A-317491, in rat models of neuropathic, chemogenic, and inflammatory pain." | 3.73 | Endogenous opioid mechanisms partially mediate P2X3/P2X2/3-related antinociception in rat models of inflammatory and chemogenic pain but not neuropathic pain. ( Bianchi, B; Faltynek, CR; Honore, P; Jarvis, MF; McDonald, HA; McGaraughty, S; Mikusa, J; Wismer, CT; Zhu, CZ, 2005) |
| "Suramin was found to curb the inflammation associated with the collagen induced arthritis (CIA) model." | 1.46 | Antioxidant activity and protective effect of suramin against oxidative stress in collagen induced arthritis. ( Panda, AK; Sahu, D; Sharma, S; Singla, RK, 2017) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (25.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 2 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sahu, D | 2 |
| Sharma, S | 1 |
| Singla, RK | 1 |
| Panda, AK | 1 |
| Saroha, A | 1 |
| Roy, S | 1 |
| Das, S | 1 |
| Srivastava, PS | 1 |
| Das, HR | 1 |
| McGaraughty, S | 1 |
| Honore, P | 1 |
| Wismer, CT | 1 |
| Mikusa, J | 1 |
| Zhu, CZ | 1 |
| McDonald, HA | 1 |
| Bianchi, B | 1 |
| Faltynek, CR | 1 |
| Jarvis, MF | 1 |
| Ackerman, NR | 1 |
| Jubb, S | 1 |
| Trimble, B | 1 |
| Marlowe, S | 1 |
| Miram, L | 1 |
| Maloney, P | 1 |
4 other studies available for suramin and Adjuvant Arthritis
| Article | Year |
|---|---|
Antioxidant activity and protective effect of suramin against oxidative stress in collagen induced arthritis.
Topics: Animals; Antioxidants; Arthritis, Experimental; Ascorbic Acid; Catalase; Cell Line; Collagen; Female | 2017 |
Suramin ameliorates collagen induced arthritis.
Topics: Acute-Phase Proteins; Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Arthritis, Rheumat | 2012 |
Endogenous opioid mechanisms partially mediate P2X3/P2X2/3-related antinociception in rat models of inflammatory and chemogenic pain but not neuropathic pain.
Topics: Analgesia; Animals; Arthritis, Experimental; Dose-Response Relationship, Drug; Endorphins; Formaldeh | 2005 |
Divergent effects of suramin on in vitro and in vivo assays of cartilage degradation.
Topics: Animals; Arthritis, Experimental; Aspartic Acid Endopeptidases; Bone Resorption; Cartilage, Articula | 1983 |