suramin has been researched along with Addison Disease in 2 studies
Suramin: A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.
suramin : A member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years.
Addison Disease: An adrenal disease characterized by the progressive destruction of the ADRENAL CORTEX, resulting in insufficient production of ALDOSTERONE and HYDROCORTISONE. Clinical symptoms include ANOREXIA; NAUSEA; WEIGHT LOSS; MUSCLE WEAKNESS; and HYPERPIGMENTATION of the SKIN due to increase in circulating levels of ACTH precursor hormone which stimulates MELANOCYTES.
| Excerpt | Relevance | Reference |
|---|---|---|
| " There appeared to be a cumulative dose-response relationship to the development of glucocorticoid insufficiency, with no instances being observed at doses < 4." | 2.68 | Mineralocorticoid insufficiency due to suramin therapy. ( Janisch, L; Kobayashi, K; Ratain, MJ; Vogelzang, NJ; Vokes, EE; Weiss, RE, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (50.00) | 18.7374 |
| 1990's | 1 (50.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| AZERAD, E | 1 |
| GRUPPER, C | 1 |
| Kobayashi, K | 1 |
| Weiss, RE | 1 |
| Vogelzang, NJ | 1 |
| Vokes, EE | 1 |
| Janisch, L | 1 |
| Ratain, MJ | 1 |
1 trial available for suramin and Addison Disease
| Article | Year |
|---|---|
Mineralocorticoid insufficiency due to suramin therapy.
Topics: Addison Disease; Adrenal Cortex Diseases; Adrenocorticotropic Hormone; Aged; Aldosterone; Antineopla | 1996 |
1 other study available for suramin and Addison Disease
| Article | Year |
|---|---|
[Addison's disease, pemphigus and moranyl].
Topics: Addison Disease; Adrenal Insufficiency; Hypoadrenocorticism, Familial; Pemphigus; Suramin | 1953 |