suramin has been researched along with Acute Liver Injury, Drug-Induced in 7 studies
Suramin: A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.
suramin : A member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Suramin is a synthetic polyanionic compound which is capable of altering the function of a number of biologic systems and inhibiting the activity of a variety of protein and growth factors." | 1.28 | Inhibitory effects of suramin on a human renal cell carcinoma line, causing nephrogenic hepatic dysfunction. ( Chang, SY; Kozlowski, JM; Lee, C; Sherwood, ER; Yu, DS, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (28.57) | 18.7374 |
| 1990's | 2 (28.57) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (42.86) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fourches, D | 1 |
| Barnes, JC | 1 |
| Day, NC | 1 |
| Bradley, P | 1 |
| Reed, JZ | 1 |
| Tropsha, A | 1 |
| Ali, I | 1 |
| Welch, MA | 1 |
| Lu, Y | 1 |
| Swaan, PW | 1 |
| Brouwer, KLR | 1 |
| Ayata, CK | 1 |
| Ganal, SC | 1 |
| Hockenjos, B | 1 |
| Willim, K | 1 |
| Vieira, RP | 1 |
| Grimm, M | 1 |
| Robaye, B | 1 |
| Boeynaems, JM | 1 |
| Di Virgilio, F | 1 |
| Pellegatti, P | 1 |
| Diefenbach, A | 1 |
| Idzko, M | 1 |
| Hasselblatt, P | 1 |
| Chang, SY | 1 |
| Yu, DS | 1 |
| Sherwood, ER | 1 |
| Kozlowski, JM | 1 |
| Lee, C | 1 |
| Szende, B | 1 |
| Lapis, K | 1 |
| Jeney, A | 1 |
| Simon, K | 1 |
| Ordög, A | 1 |
| Moldvay, J | 1 |
| Vakulin, GM | 1 |
| Korolenko, TA | 2 |
| Pupyshev, AB | 2 |
| Malygin, AE | 2 |
| Kurysheva, NG | 2 |
| Gavrilova, NI | 1 |
7 other studies available for suramin and Acute Liver Injury, Drug-Induced
| Article | Year |
|---|---|
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLI | 2010 |
Identification of novel MRP3 inhibitors based on computational models and validation using an in vitro membrane vesicle assay.
Topics: Aminoglycosides; Amiodarone; Bayes Theorem; Biological Transport; Cell Survival; Chemical and Drug I | 2017 |
Purinergic P2Y₂ receptors promote neutrophil infiltration and hepatocyte death in mice with acute liver injury.
Topics: Acute Disease; Adenosine Triphosphate; Animals; Apoptosis; Cell Movement; Chemical and Drug Induced | 2012 |
Inhibitory effects of suramin on a human renal cell carcinoma line, causing nephrogenic hepatic dysfunction.
Topics: Animals; Carcinoma, Renal Cell; Cell Division; Chemical and Drug Induced Liver Injury; Combined Moda | 1992 |
Liver damaging effect of suramin in normal and carbon-tetrachloride treated rats.
Topics: Animals; Body Weight; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Drug Synergism; | 1991 |
[Effect of the lysosomotropic preparation suramin on the ultrastructural and functional characteristics of rat liver cells in acute toxic hepatitis].
Topics: Acute Disease; Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Live | 1986 |
[Facilitation of the structural and functional disorders of liver lysosomes in toxic hepatitis due to the suppression of intralysosomal proteolysis].
Topics: Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Kupffer Cells; Live | 1985 |