suramin has been researched along with Acute Kidney Injury in 6 studies
Suramin: A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.
suramin : A member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years.
Acute Kidney Injury: Abrupt reduction in kidney function. Acute kidney injury encompasses the entire spectrum of the syndrome including acute kidney failure; ACUTE KIDNEY TUBULAR NECROSIS; and other less severe conditions.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Experimental evidence has indicated a role of adult renal progenitor cells in kidney regeneration and a protective role of the kidney by erythropoietin (EPO) and suramin in animal models and in humans after acute kidney injury (AKI)." | 7.79 | Mouse adult renal progenitor cells in combination with erythropoietin or suramin--a potential new strategy for the treatment of acute kidney injury. ( Wang, PR, 2013) |
| "Suramin treatment before cisplatin administration reduced cisplatin-induced decreases in kidney function and injury." | 5.43 | Suramin protects from cisplatin-induced acute kidney injury. ( Arteel, GE; Beverly, LJ; Casson, L; Doll, MA; Dupre, TV; Jenson, AB; Kiefer, A; Megyesi, J; Saforo, D; Saurabh, K; Scherzer, MT; Schnellmann, RG; Shah, PP; Sharp, CN; Siow, D; Siskind, LJ, 2016) |
| "Suramin treatment decreased interleukin-1β (IL-1β) mRNA, transforming growth factor-β(1) (TGF-β(1)), phospho-p65 of nuclear factor-κB (NF-κB), and cleaved caspase-3 at 48 h compared with glycerol alone." | 5.38 | Recovery from glycerol-induced acute kidney injury is accelerated by suramin. ( Korrapati, MC; Schnellmann, RG; Shaner, BE, 2012) |
| "Experimental evidence has indicated a role of adult renal progenitor cells in kidney regeneration and a protective role of the kidney by erythropoietin (EPO) and suramin in animal models and in humans after acute kidney injury (AKI)." | 3.79 | Mouse adult renal progenitor cells in combination with erythropoietin or suramin--a potential new strategy for the treatment of acute kidney injury. ( Wang, PR, 2013) |
| "Suramin treatment before cisplatin administration reduced cisplatin-induced decreases in kidney function and injury." | 1.43 | Suramin protects from cisplatin-induced acute kidney injury. ( Arteel, GE; Beverly, LJ; Casson, L; Doll, MA; Dupre, TV; Jenson, AB; Kiefer, A; Megyesi, J; Saforo, D; Saurabh, K; Scherzer, MT; Schnellmann, RG; Shah, PP; Sharp, CN; Siow, D; Siskind, LJ, 2016) |
| "Suramin treatment decreased interleukin-1β (IL-1β) mRNA, transforming growth factor-β(1) (TGF-β(1)), phospho-p65 of nuclear factor-κB (NF-κB), and cleaved caspase-3 at 48 h compared with glycerol alone." | 1.38 | Recovery from glycerol-induced acute kidney injury is accelerated by suramin. ( Korrapati, MC; Schnellmann, RG; Shaner, BE, 2012) |
| "Suramin has demonstrated modest activity against prostate cancer and is being investigated in clinical trials." | 1.30 | Acute renal failure in a patient receiving treatment with suramin. ( Harbour, D; Liebmann, J; Smith, A, 1997) |
| "His suramin therapy was discontinued, but his serum creatinine level continued to rise to 10." | 1.29 | Acute renal toxicity associated with suramin in the treatment of prostate cancer. ( Bergan, RC; Cooper, MR; Figg, WD; Headlee, D; Humphrey, J; Reed, E; Sartor, O; Thibault, A, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (33.33) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 4 (66.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Han, X | 1 |
| Zhao, L | 1 |
| Lu, G | 1 |
| Ge, J | 1 |
| Zhao, Y | 1 |
| Zu, S | 1 |
| Yuan, M | 1 |
| Liu, Y | 1 |
| Kong, F | 1 |
| Xiao, Z | 1 |
| Zhao, S | 1 |
| Wang, PR | 1 |
| Dupre, TV | 1 |
| Doll, MA | 1 |
| Shah, PP | 1 |
| Sharp, CN | 1 |
| Kiefer, A | 1 |
| Scherzer, MT | 1 |
| Saurabh, K | 1 |
| Saforo, D | 1 |
| Siow, D | 1 |
| Casson, L | 1 |
| Arteel, GE | 1 |
| Jenson, AB | 1 |
| Megyesi, J | 1 |
| Schnellmann, RG | 2 |
| Beverly, LJ | 1 |
| Siskind, LJ | 1 |
| Korrapati, MC | 1 |
| Shaner, BE | 1 |
| Figg, WD | 1 |
| Cooper, MR | 1 |
| Thibault, A | 1 |
| Headlee, D | 1 |
| Humphrey, J | 1 |
| Bergan, RC | 1 |
| Reed, E | 1 |
| Sartor, O | 1 |
| Smith, A | 1 |
| Harbour, D | 1 |
| Liebmann, J | 1 |
6 other studies available for suramin and Acute Kidney Injury
| Article | Year |
|---|---|
Improving outcomes of acute kidney injury using mouse renal progenitor cells alone or in combination with erythropoietin or suramin.
Topics: Acute Kidney Injury; Adult Stem Cells; Animals; Antigens, CD34; Cadherins; Cell Differentiation; Cel | 2013 |
Mouse adult renal progenitor cells in combination with erythropoietin or suramin--a potential new strategy for the treatment of acute kidney injury.
Topics: Acute Kidney Injury; Adult Stem Cells; Animals; Erythropoietin; Hematinics; Kidney; Male; Suramin | 2013 |
Suramin protects from cisplatin-induced acute kidney injury.
Topics: Acute Kidney Injury; Adenocarcinoma; Adenocarcinoma of Lung; Animals; Apoptosis; Cell Line, Tumor; C | 2016 |
Recovery from glycerol-induced acute kidney injury is accelerated by suramin.
Topics: Acute Kidney Injury; Animals; Glycerol; Inflammation Mediators; Male; Rats; Rats, Sprague-Dawley; Re | 2012 |
Acute renal toxicity associated with suramin in the treatment of prostate cancer.
Topics: Acute Kidney Injury; Antineoplastic Combined Chemotherapy Protocols; Carcinoma; Combined Modality Th | 1994 |
Acute renal failure in a patient receiving treatment with suramin.
Topics: Acute Kidney Injury; Adenocarcinoma; Androgen Antagonists; Anti-Inflammatory Agents; Antineoplastic | 1997 |