suramin has been researched along with Acute Hepatic Failure in 2 studies
Suramin: A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.
suramin : A member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Suramin is a symmetrical polysulfonated naphthylamine derivative of urea." | 1.33 | Suramin prevents fulminant hepatic failure resulting in reduction of lethality through the suppression of NF-kappaB activity. ( Endo, A; Goto, T; Kataoka, E; Mikami, K; Miura, K; Ohshima, S; Sato, M; Sato, W; Segawa, D; Shibuya, T; Takeuchi, S; Watanabe, D; Watanabe, S; Yoneyama, K; Yoshino, R, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Doggrell, SA | 1 |
| Goto, T | 1 |
| Takeuchi, S | 1 |
| Miura, K | 1 |
| Ohshima, S | 1 |
| Mikami, K | 1 |
| Yoneyama, K | 1 |
| Sato, M | 1 |
| Shibuya, T | 1 |
| Watanabe, D | 1 |
| Kataoka, E | 1 |
| Segawa, D | 1 |
| Endo, A | 1 |
| Sato, W | 1 |
| Yoshino, R | 1 |
| Watanabe, S | 1 |
1 review available for suramin and Acute Hepatic Failure
| Article | Year |
|---|---|
Suramin: potential in acute liver failure.
Topics: Animals; Apoptosis; Disease Models, Animal; Humans; Liver Failure, Acute; Suramin | 2004 |
1 other study available for suramin and Acute Hepatic Failure
| Article | Year |
|---|---|
Suramin prevents fulminant hepatic failure resulting in reduction of lethality through the suppression of NF-kappaB activity.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Cell Line; Cytokines; Galactosamine; Int | 2006 |