suramin has been researched along with Acquired Immunodeficiency Syndrome in 43 studies
Suramin: A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.
suramin : A member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years.
Acquired Immunodeficiency Syndrome: An acquired defect of cellular immunity associated with infection by the human immunodeficiency virus (HIV), a CD4-positive T-lymphocyte count under 200 cells/microliter or less than 14% of total lymphocytes, and increased susceptibility to opportunistic infections and malignant neoplasms. Clinical manifestations also include emaciation (wasting) and dementia. These elements reflect criteria for AIDS as defined by the CDC in 1993.
| Excerpt | Relevance | Reference |
|---|---|---|
| " We treated 12 patients who had acquired immunodeficiency syndrome and active HTLV-III/LAV viremia with suramin, a potent competitive inhibitor of reverse transcriptase, in six weekly induction doses of 1 g, followed by weekly maintenance doses of 500 mg." | 7.67 | Suramin antiviral therapy in the acquired immunodeficiency syndrome. Clinical, immunological, and virologic results. ( Aguilar, S; Cohen, J; Formenti, SC; Gill, PS; Hawkins, JG; Krailo, M; Levine, AM; Meyer, PR; Parker, J; Rasheed, S, 1986) |
| "Suramin is a toxic agent that shows no virologic, immunologic, or clinical benefit in patients with HIV-related disease." | 6.66 | Lack of response to suramin in patients with AIDS and AIDS-related complex. ( Abrams, DI; Feorino, P; Gottlieb, MS; Kaplan, LD; Kaufman, L; Kiprov, D; Levy, JA; Volberding, PA; Wolfe, PR; Wong, R, 1987) |
| "Ten homosexual men with the acquired immunodeficiency syndrome were included in a serologic follow-up study (duration, 40 weeks) of human immunodeficiency virus (HIV) antigenemia." | 5.27 | Persistence of human immunodeficiency virus antigenemia in patients with the acquired immunodeficiency syndrome treated with a reverse transcriptase inhibitor, suramin. Ten-patient case-control study. ( Danner, SA; Eeftinck Schattenkerk, JK; Goudsmit, J; Lange, JM; Miedema, F; Paul, DA; Schellekens, PT; van Boxtel, CJ, 1988) |
| "Suramin has been reported to inhibit the reverse transcriptase activity of a number of retroviruses and to reduce the in vitro infectivity and cytopathic effect of HTLV-III/LAV, the etiologic agent of acquired immune deficiency syndrome (AIDS)." | 5.06 | Clinical pharmacokinetics of suramin in patients with HTLV-III/LAV infection. ( Broder, S; Collins, JM; Fauci, AS; Klecker, RW; Lane, HC; Myers, CE; Redfield, RR; Yarchoan, R, 1986) |
| " We treated 12 patients who had acquired immunodeficiency syndrome and active HTLV-III/LAV viremia with suramin, a potent competitive inhibitor of reverse transcriptase, in six weekly induction doses of 1 g, followed by weekly maintenance doses of 500 mg." | 3.67 | Suramin antiviral therapy in the acquired immunodeficiency syndrome. Clinical, immunological, and virologic results. ( Aguilar, S; Cohen, J; Formenti, SC; Gill, PS; Hawkins, JG; Krailo, M; Levine, AM; Meyer, PR; Parker, J; Rasheed, S, 1986) |
| "Suramin has recently been used to treat patients with acquired immune deficiency syndrome because of the action of this drug on reverse transcriptase." | 3.67 | The inhibition of human adrenal steroidogenic enzyme activities by suramin. ( Albertson, BD; Ashby, H; DiMattina, M; Linehan, WM; Queenan, JT; Robertson, CN, 1989) |
| "Suramin was given to ten outpatients with acquired immunodeficiency syndrome (AIDS) presenting as Kaposi's sarcoma (KS) or as an AIDS-related complex (ARC)." | 3.67 | Effects of suramin on HTLV-III/LAV infection presenting as Kaposi's sarcoma or AIDS-related complex: clinical pharmacology and suppression of virus replication in vivo. ( Broder, S; Collins, JM; Gelmann, E; Hoth, DF; Klecker, RW; Lane, HC; Markham, PD; Mitsuya, H; Redfield, RR; Yarchoan, R, 1985) |
| "Suramin sodium is a reverse transcriptase inhibitor with in vitro activity against the human immunodeficiency virus (HIV), the causative agent of acquired immunodeficiency syndrome (AIDS)." | 3.67 | Suramin therapy in AIDS and related disorders. Report of the US Suramin Working Group. ( Cheson, BD; Gill, P; Groopman, JE; Kaplan, LD; Levine, AM; Mildvan, D; Poiesz, BJ; Rios, A; Volberding, PA; Wolfe, P, 1987) |
| "The pathogenesis of AIDS involves the destruction of helper/inducer T-lymphocytes by active viral infection, and drugs which inhibit the replication of HTLV-III or monoclonal antibodies directed at viral antigens may be important components of future therapeutic strategies." | 2.66 | Implications of the discovery of HTLV-III for the treatment of AIDS. ( Broder, S; Matsushita, S; Mitsuya, H; Yarchoan, R, 1985) |
| "Suramin is a toxic agent that shows no virologic, immunologic, or clinical benefit in patients with HIV-related disease." | 2.66 | Lack of response to suramin in patients with AIDS and AIDS-related complex. ( Abrams, DI; Feorino, P; Gottlieb, MS; Kaplan, LD; Kaufman, L; Kiprov, D; Levy, JA; Volberding, PA; Wolfe, PR; Wong, R, 1987) |
| "Suramin is a drug used in the therapy of Rhodesian trypanosomiasis and onchocerciasis, and it inhibits the reverse transcriptase of a number of retroviruses including HTLV-III." | 2.37 | Protection of T cells against infectivity and cytopathic effect of HTLV-III in vitro. ( Broder, S; Matsushita, S; Mitsuya, H; Yarchoan, R, 1984) |
| "Suramin is a potent inhibitor of the reverse transcriptase (RNA-directed DNA polymerase) of retroviruses, including the HTLV-III/LAV (human T-cell lymphotropic virus type III/lymphadenopathy-associated virus) reverse transcriptase." | 2.37 | Suramin in the treatment of AIDS: mechanism of action. ( De Clercq, E, 1987) |
| "The end-stage of these infections, acquired immune deficiency syndrome (AIDS), was first recognised in 1981, and the causative agent isolated in 1983." | 2.37 | Antiviral therapy in AIDS. Clinical pharmacological properties and therapeutic experience to date. ( Kaplan, JC; Sandström, EG, 1987) |
| "Ten homosexual men with the acquired immunodeficiency syndrome were included in a serologic follow-up study (duration, 40 weeks) of human immunodeficiency virus (HIV) antigenemia." | 1.27 | Persistence of human immunodeficiency virus antigenemia in patients with the acquired immunodeficiency syndrome treated with a reverse transcriptase inhibitor, suramin. Ten-patient case-control study. ( Danner, SA; Eeftinck Schattenkerk, JK; Goudsmit, J; Lange, JM; Miedema, F; Paul, DA; Schellekens, PT; van Boxtel, CJ, 1988) |
| "Suramin was found to produce a positive DAT in vitro at concentrations of 2100 mg/L or greater but did not cause a positive DAT in five patients with acquired immunodeficiency syndrome who were treated with suramin, probably because the serum levels of suramin were too low in these patients (peak therapeutic blood levels ranged from 171 to 443 mg/L)." | 1.27 | Production of a positive direct antiglobulin test due to suramin. ( Aguilar, S; Cohen, J; Gill, P; Jamin, D; Lam, HT; Levine, A; Shields, M; Shulman, I, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 39 (90.70) | 18.7374 |
| 1990's | 3 (6.98) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (2.33) | 2.80 |
| Authors | Studies |
|---|---|
| Mohan, P | 1 |
| Singh, R | 1 |
| Baba, M | 1 |
| De Clercq, E | 6 |
| Mitsuya, H | 3 |
| Matsushita, S | 2 |
| Yarchoan, R | 6 |
| Broder, S | 6 |
| Opocher, G | 1 |
| Mantero, F | 1 |
| Voogd, TE | 1 |
| Vansterkenburg, EL | 1 |
| Wilting, J | 1 |
| Janssen, LH | 1 |
| Chandra, P | 1 |
| Vogel, A | 1 |
| Gerber, T | 1 |
| Hirsch, MS | 2 |
| Kaplan, JC | 2 |
| Bogdan, C | 1 |
| Solbach, W | 1 |
| Balzarini, J | 1 |
| Levine, AM | 2 |
| Gill, PS | 1 |
| Cohen, J | 2 |
| Hawkins, JG | 1 |
| Formenti, SC | 1 |
| Aguilar, S | 2 |
| Meyer, PR | 1 |
| Krailo, M | 1 |
| Parker, J | 1 |
| Rasheed, S | 1 |
| Gupta, S | 1 |
| Gottlieb, MS | 2 |
| Vogt, M | 1 |
| Schooley, RT | 2 |
| Pomerantz, RJ | 1 |
| Eeftinck Schattenkerk, JK | 1 |
| Danner, SA | 1 |
| Lange, JM | 2 |
| Paul, DA | 1 |
| van Boxtel, CJ | 1 |
| Miedema, F | 1 |
| Schellekens, PT | 1 |
| Goudsmit, J | 1 |
| Ashby, H | 1 |
| DiMattina, M | 1 |
| Linehan, WM | 1 |
| Robertson, CN | 1 |
| Queenan, JT | 1 |
| Albertson, BD | 1 |
| Teirlynck, O | 1 |
| Bogaert, MG | 1 |
| Demedts, P | 1 |
| Taelman, H | 1 |
| Sandström, EG | 1 |
| Rouvroy, D | 1 |
| Bogaerts, J | 1 |
| Habyarimana, JB | 1 |
| Nzaramba, D | 1 |
| Van de Perre, P | 1 |
| Zagury, D | 1 |
| Gagne, I | 1 |
| Réveil, B | 1 |
| Bernard, J | 1 |
| Zagury, JF | 1 |
| Saimot, AG | 1 |
| Sarin, PS | 1 |
| Gallo, RC | 2 |
| Collins, JM | 2 |
| Lane, HC | 3 |
| Markham, PD | 2 |
| Klecker, RW | 2 |
| Redfield, RR | 2 |
| Hoth, DF | 1 |
| Gelmann, E | 1 |
| Busch, W | 2 |
| Brodt, R | 2 |
| Ganser, A | 2 |
| Helm, EB | 2 |
| Stille, W | 2 |
| Sandström, E | 1 |
| Weber, J | 1 |
| Fauci, AS | 2 |
| Riesenberg, DE | 1 |
| Marwick, C | 1 |
| Myers, CE | 1 |
| Barnes, DM | 1 |
| Verdonck, LF | 1 |
| de Gast, GC | 1 |
| Schuurman, HJ | 1 |
| Dekker, AW | 1 |
| Bast, BJ | 1 |
| Rada, B | 1 |
| Jamin, D | 1 |
| Shulman, I | 1 |
| Lam, HT | 1 |
| Shields, M | 1 |
| Gill, P | 2 |
| Levine, A | 1 |
| Raise, E | 1 |
| Gritti, FM | 1 |
| Bonazzi, L | 1 |
| Monti, M | 1 |
| Grillo, A | 1 |
| Savoia, M | 1 |
| Gambetti, M | 1 |
| Pulsatelli, L | 1 |
| Casertano, MG | 1 |
| Di Figlia, C | 1 |
| Kaplan, LD | 2 |
| Wolfe, PR | 1 |
| Volberding, PA | 2 |
| Feorino, P | 1 |
| Levy, JA | 1 |
| Abrams, DI | 1 |
| Kiprov, D | 1 |
| Wong, R | 1 |
| Kaufman, L | 1 |
| Resnick, L | 1 |
| Veren, K | 1 |
| Salahuddin, SZ | 1 |
| Cheson, BD | 1 |
| Mildvan, D | 2 |
| Wolfe, P | 1 |
| Rios, A | 1 |
| Groopman, JE | 1 |
| Poiesz, BJ | 1 |
| Teich, SA | 1 |
| Handwerger, S | 1 |
| Mathur-Wagh, U | 1 |
| Yancovitz, S | 1 |
| Desnick, RJ | 1 |
| Stein, CA | 1 |
| Saville, W | 1 |
| Gelmann, EP | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Phase II Trial of Leuprolide + Flutamide + Suramin in Untreated Poor Prognosis Prostate Carcinoma[NCT00001266] | Phase 2 | 70 participants | Interventional | 1990-10-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
15 reviews available for suramin and Acquired Immunodeficiency Syndrome
| Article | Year |
|---|---|
Chemotherapeutic approaches to the treatment of the acquired immune deficiency syndrome (AIDS).
Topics: Acquired Immunodeficiency Syndrome; Adsorption; Antibodies, Viral; Antigens, Viral; Aurintricarboxyl | 1986 |
Protection of T cells against infectivity and cytopathic effect of HTLV-III in vitro.
Topics: Acquired Immunodeficiency Syndrome; Cytopathogenic Effect, Viral; Deltaretrovirus; Humans; Reverse T | 1984 |
Adrenal complications of HIV infection.
Topics: Acquired Immunodeficiency Syndrome; Adrenal Cortex; Adrenal Gland Diseases; AIDS-Related Opportunist | 1994 |
Recent research on the biological activity of suramin.
Topics: Acquired Immunodeficiency Syndrome; Animals; Filarioidea; Humans; Neoplasms; Onchocerciasis; Recepto | 1993 |
Inhibitors of retroviral DNA polymerase: their implication in the treatment of AIDS.
Topics: Acquired Immunodeficiency Syndrome; Cell Line; Deltaretrovirus; DNA Nucleotidylexotransferase; Human | 1985 |
Prospects of therapy for infections with human T-lymphotropic virus type III.
Topics: Acquired Immunodeficiency Syndrome; Anti-Bacterial Agents; Antimony; Antiviral Agents; Combined Moda | 1985 |
[The acquired immunodeficiency syndrome (AIDS)].
Topics: Acquired Immunodeficiency Syndrome; Adult; Child; Cross Infection; Female; Humans; Male; Retrovirida | 1985 |
Suramin in the treatment of AIDS: mechanism of action.
Topics: Acquired Immunodeficiency Syndrome; Cytopathogenic Effect, Viral; HIV; Humans; Reverse Transcriptase | 1987 |
Therapy of human immunodeficiency virus infections.
Topics: Acquired Immunodeficiency Syndrome; Antiviral Agents; Foscarnet; Humans; Immunotherapy; Interferons; | 1987 |
Antiviral therapy in AIDS. Clinical pharmacological properties and therapeutic experience to date.
Topics: Acquired Immunodeficiency Syndrome; Antimony; Antiviral Agents; Forecasting; Foscarnet; Immunotherap | 1987 |
Progress in the development of antiviral therapy for HTLV-III-associated diseases.
Topics: Acquired Immunodeficiency Syndrome; Antimony; Antiviral Agents; Foscarnet; HIV; Humans; Phosphonoace | 1987 |
Perspectives for the chemotherapy of AIDS.
Topics: Acquired Immunodeficiency Syndrome; Glycyrrhetinic Acid; Glycyrrhizic Acid; HIV; Humans; Polysacchar | 1988 |
Antiviral drugs for AIDS. Current status and future prospects.
Topics: Acquired Immunodeficiency Syndrome; Antimony; Antiviral Agents; Foscarnet; Humans; Interferon Type I | 1986 |
Immunologic reconstitution in the acquired immunodeficiency syndrome.
Topics: Acquired Immunodeficiency Syndrome; Adjuvants, Immunologic; Antimony; Antiviral Agents; Bone Marrow | 1985 |
[Experimental chemotherapy of AIDS].
Topics: Acquired Immunodeficiency Syndrome; Amphotericin B; Antimony; Antiviral Agents; Humans; Oligopeptide | 1988 |
4 trials available for suramin and Acquired Immunodeficiency Syndrome
| Article | Year |
|---|---|
Implications of the discovery of HTLV-III for the treatment of AIDS.
Topics: Acquired Immunodeficiency Syndrome; Clinical Trials as Topic; Deltaretrovirus; DNA, Viral; Humans; L | 1985 |
[Chemotherapy and immunoprophylaxis of HIV infection].
Topics: Acquired Immunodeficiency Syndrome; Antiviral Agents; Clinical Trials as Topic; Foscarnet; HIV; Huma | 1986 |
Clinical pharmacokinetics of suramin in patients with HTLV-III/LAV infection.
Topics: Acquired Immunodeficiency Syndrome; Blood Proteins; Clinical Trials as Topic; Deltaretrovirus; Half- | 1986 |
Lack of response to suramin in patients with AIDS and AIDS-related complex.
Topics: Acquired Immunodeficiency Syndrome; Adult; AIDS-Related Complex; Clinical Trials as Topic; Drug Admi | 1987 |
24 other studies available for suramin and Acquired Immunodeficiency Syndrome
| Article | Year |
|---|---|
Potential anti-AIDS agents. Synthesis and antiviral activity of naphthalenesulfonic acid derivatives against HIV-1 and HIV-2.
Topics: Acquired Immunodeficiency Syndrome; Antiviral Agents; Cell Line; Cell Survival; HIV-1; HIV-2; Humans | 1991 |
1984-Discovery of the First Anti-HIV Drug, Suramin.
Topics: Acquired Immunodeficiency Syndrome; Anti-HIV Agents; Drug Discovery; History, 20th Century; History, | 2021 |
In search of specific inhibitors of retrovirus replication.
Topics: Acquired Immunodeficiency Syndrome; Amidines; Animals; Antiviral Agents; Cell Transformation, Neopla | 1985 |
Suramin antiviral therapy in the acquired immunodeficiency syndrome. Clinical, immunological, and virologic results.
Topics: Acquired Immunodeficiency Syndrome; Adult; Antibodies, Viral; Cerebrospinal Fluid; Deltaretrovirus; | 1986 |
Treatment of the acquired immune deficiency syndrome.
Topics: Acquired Immunodeficiency Syndrome; Antibodies, Monoclonal; Antiviral Agents; Bone Marrow Transplant | 1986 |
Persistence of human immunodeficiency virus antigenemia in patients with the acquired immunodeficiency syndrome treated with a reverse transcriptase inhibitor, suramin. Ten-patient case-control study.
Topics: Acquired Immunodeficiency Syndrome; Adult; Antigens, Viral; HIV; HIV Antigens; Humans; Lymphocytes; | 1988 |
The inhibition of human adrenal steroidogenic enzyme activities by suramin.
Topics: Acquired Immunodeficiency Syndrome; Adrenal Cortex; Humans; Hydroxysteroid Dehydrogenases; Microsome | 1989 |
Rapid high-performance liquid chromatographic determination of suramin in plasma of patients with acquired immune deficiency syndrome (AIDS) or AIDS-related complex (ARC).
Topics: Acquired Immunodeficiency Syndrome; AIDS-Related Complex; Chromatography, High Pressure Liquid; Huma | 1989 |
[Perspectives in AIDS chemotherapy].
Topics: Acquired Immunodeficiency Syndrome; Antiviral Agents; Dideoxynucleosides; Glycyrrhetinic Acid; Glycy | 1989 |
Short-term results with suramin for AIDS-related conditions.
Topics: Acquired Immunodeficiency Syndrome; Adult; Diarrhea; Female; Humans; Lymphatic Diseases; Male; Suram | 1985 |
Repairing the T-cell defect in AIDS.
Topics: Acquired Immunodeficiency Syndrome; Humans; Interleukin-2; Suramin; T-Lymphocytes | 1985 |
Effects of suramin on HTLV-III/LAV infection presenting as Kaposi's sarcoma or AIDS-related complex: clinical pharmacology and suppression of virus replication in vivo.
Topics: Acquired Immunodeficiency Syndrome; Adult; Deltaretrovirus; Humans; Male; Middle Aged; Retroviridae | 1985 |
Suramin treatment for AIDS.
Topics: Acquired Immunodeficiency Syndrome; Adult; Humans; Male; Middle Aged; Suramin | 1985 |
AIDS: the virus, antivirals and vaccines.
Topics: Acquired Immunodeficiency Syndrome; Antimony; Antiviral Agents; Foscarnet; Genes, Viral; HIV; Humans | 1987 |
Anti-AIDS agents show varying early results in vitro and in vivo.
Topics: Acquired Immunodeficiency Syndrome; Antimony; Antiviral Agents; Deltaretrovirus; Humans; Ribavirin; | 1985 |
In search of the best drugs against AIDS.
Topics: Acquired Immunodeficiency Syndrome; Deltaretrovirus; Humans; Ribavirin; Suramin; Thymidine; Zidovudi | 1986 |
Syngeneic leukocytes together with suramin failed to improve immunodeficiency in a case of transfusion-associated AIDS after syngeneic bone marrow transplantation.
Topics: Acquired Immunodeficiency Syndrome; Adult; Antigens, Viral; Blood Donors; Bone Marrow Transplantatio | 1988 |
Production of a positive direct antiglobulin test due to suramin.
Topics: Acquired Immunodeficiency Syndrome; Coombs Test; Dose-Response Relationship, Drug; Erythrocytes; Fem | 1988 |
R-interferon alpha A and suramin sodium in the treatment of AIDS and ARC cases.
Topics: Acquired Immunodeficiency Syndrome; Adult; AIDS-Related Complex; Female; Humans; Interferon Type I; | 1987 |
In vitro suppression of HTLV-III/LAV infectivity by a combination of acyclovir and suramin.
Topics: Acquired Immunodeficiency Syndrome; Acyclovir; Dose-Response Relationship, Drug; Drug Synergism; HIV | 1986 |
Suramin therapy in AIDS and related disorders. Report of the US Suramin Working Group.
Topics: Acquired Immunodeficiency Syndrome; Adult; AIDS-Related Complex; Drug Evaluation; Female; HIV; Human | 1987 |
Toxic keratopathy associated with suramin therapy.
Topics: Acquired Immunodeficiency Syndrome; Corneal Diseases; Humans; Suramin | 1986 |
Suramin and function of the adrenal cortex.
Topics: Acquired Immunodeficiency Syndrome; Adrenal Cortex Diseases; Adult; Humans; Male; Suramin | 1986 |
[Suramin therapy in patients with LAS/AIDS].
Topics: Acquired Immunodeficiency Syndrome; Adult; Humans; Lymphatic Diseases; Male; Suramin | 1985 |