suramin has been researched along with Acanthamoeba Meningoencephalitis in 1 studies
Suramin: A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.
suramin : A member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Relapses were significantly correlated with intrathecal IgM synthesis (odds ratio [OR], 46; 95% confidence interval [CI], 8 to 260), a CSF IgM concentration of >or=1." | 1.34 | Treatment failure related to intrathecal immunoglobulin M (IgM) synthesis, cerebrospinal fluid IgM, and interleukin-10 in patients with hemolymphatic-stage sleeping sickness. ( Bisser, S; Boelaert, M; Büscher, P; Hoogstoel, A; Lejon, V; Mumba, D; N'Siesi, FX; Reiber, H; Robays, J, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lejon, V | 1 |
| Robays, J | 1 |
| N'Siesi, FX | 1 |
| Mumba, D | 1 |
| Hoogstoel, A | 1 |
| Bisser, S | 1 |
| Reiber, H | 1 |
| Boelaert, M | 1 |
| Büscher, P | 1 |
1 other study available for suramin and Acanthamoeba Meningoencephalitis
| Article | Year |
|---|---|
Treatment failure related to intrathecal immunoglobulin M (IgM) synthesis, cerebrospinal fluid IgM, and interleukin-10 in patients with hemolymphatic-stage sleeping sickness.
Topics: Adolescent; Adult; Aged; Animals; Antibodies, Protozoan; Biomarkers; Central Nervous System Protozoa | 2007 |