suramin has been researched along with Abnormalities, Drug-Induced in 5 studies
Suramin: A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.
suramin : A member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years.
Abnormalities, Drug-Induced: Congenital abnormalities caused by medicinal substances or drugs of abuse given to or taken by the mother, or to which she is inadvertently exposed during the manufacture of such substances. The concept excludes abnormalities resulting from exposure to non-medicinal chemicals in the environment.
| Excerpt | Relevance | Reference |
|---|---|---|
| "When suramin (2-10 mg/ml) was present for the final 6 h of culture, the quantity of radioactivity measured in the yolk sac at harvesting was significantly decreased in a concentration-dependent manner." | 1.27 | Evidence that suramin and aurothiomalate are teratogenic in rat by disturbing yolk sac-mediated embryonic protein nutrition. ( Freeman, SJ; Lloyd, JB, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Mercier-Parot, L | 3 |
| Tuchmann-Duplessis, H | 3 |
| Freeman, SJ | 1 |
| Lloyd, JB | 2 |
| Beck, F | 1 |
5 other studies available for suramin and Abnormalities, Drug-Induced
| Article | Year |
|---|---|
[Trial prevention of the embryolethal properties of suramin in the mouse by adjuvant progesterone].
Topics: Abnormalities, Drug-Induced; Animals; Dose-Response Relationship, Drug; Female; Fetal Death; Mice; P | 1975 |
Evidence that suramin and aurothiomalate are teratogenic in rat by disturbing yolk sac-mediated embryonic protein nutrition.
Topics: Abnormalities, Drug-Induced; Animals; Embryo, Mammalian; Female; Gold Sodium Thiomalate; Pinocytosis | 1986 |
[Effect of suramine on perinatal and postnatal survival in mice].
Topics: Abnormalities, Drug-Induced; Abortifacient Agents; Animals; Animals, Newborn; Female; Fetus; Gestati | 1973 |
[Abortifacient and teratogenic effect of suramin, a trypanocide].
Topics: Abnormalities, Drug-Induced; Abortion, Spontaneous; Animals; Dose-Response Relationship, Drug; Embry | 1973 |
Lysosomes and congenital malformations.
Topics: Abnormalities, Drug-Induced; Animals; Azo Compounds; Cortisone; Female; Lysosomes; Pregnancy; Rats; | 1969 |