suramin has been researched along with ARC in 4 studies
Suramin: A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.
suramin : A member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Suramin is a toxic agent that shows no virologic, immunologic, or clinical benefit in patients with HIV-related disease." | 6.66 | Lack of response to suramin in patients with AIDS and AIDS-related complex. ( Abrams, DI; Feorino, P; Gottlieb, MS; Kaplan, LD; Kaufman, L; Kiprov, D; Levy, JA; Volberding, PA; Wolfe, PR; Wong, R, 1987) |
| "Suramin sodium is a reverse transcriptase inhibitor with in vitro activity against the human immunodeficiency virus (HIV), the causative agent of acquired immunodeficiency syndrome (AIDS)." | 3.67 | Suramin therapy in AIDS and related disorders. Report of the US Suramin Working Group. ( Cheson, BD; Gill, P; Groopman, JE; Kaplan, LD; Levine, AM; Mildvan, D; Poiesz, BJ; Rios, A; Volberding, PA; Wolfe, P, 1987) |
| "Suramin is a toxic agent that shows no virologic, immunologic, or clinical benefit in patients with HIV-related disease." | 2.66 | Lack of response to suramin in patients with AIDS and AIDS-related complex. ( Abrams, DI; Feorino, P; Gottlieb, MS; Kaplan, LD; Kaufman, L; Kiprov, D; Levy, JA; Volberding, PA; Wolfe, PR; Wong, R, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Teirlynck, O | 1 |
| Bogaert, MG | 1 |
| Demedts, P | 1 |
| Taelman, H | 1 |
| Raise, E | 1 |
| Gritti, FM | 1 |
| Bonazzi, L | 1 |
| Monti, M | 1 |
| Grillo, A | 1 |
| Savoia, M | 1 |
| Gambetti, M | 1 |
| Pulsatelli, L | 1 |
| Casertano, MG | 1 |
| Di Figlia, C | 1 |
| Kaplan, LD | 2 |
| Wolfe, PR | 1 |
| Volberding, PA | 2 |
| Feorino, P | 1 |
| Levy, JA | 1 |
| Abrams, DI | 1 |
| Kiprov, D | 1 |
| Wong, R | 1 |
| Kaufman, L | 1 |
| Gottlieb, MS | 1 |
| Cheson, BD | 1 |
| Levine, AM | 1 |
| Mildvan, D | 1 |
| Wolfe, P | 1 |
| Rios, A | 1 |
| Groopman, JE | 1 |
| Gill, P | 1 |
| Poiesz, BJ | 1 |
1 trial available for suramin and ARC
| Article | Year |
|---|---|
Lack of response to suramin in patients with AIDS and AIDS-related complex.
Topics: Acquired Immunodeficiency Syndrome; Adult; AIDS-Related Complex; Clinical Trials as Topic; Drug Admi | 1987 |
3 other studies available for suramin and ARC
| Article | Year |
|---|---|
Rapid high-performance liquid chromatographic determination of suramin in plasma of patients with acquired immune deficiency syndrome (AIDS) or AIDS-related complex (ARC).
Topics: Acquired Immunodeficiency Syndrome; AIDS-Related Complex; Chromatography, High Pressure Liquid; Huma | 1989 |
R-interferon alpha A and suramin sodium in the treatment of AIDS and ARC cases.
Topics: Acquired Immunodeficiency Syndrome; Adult; AIDS-Related Complex; Female; Humans; Interferon Type I; | 1987 |
Suramin therapy in AIDS and related disorders. Report of the US Suramin Working Group.
Topics: Acquired Immunodeficiency Syndrome; Adult; AIDS-Related Complex; Drug Evaluation; Female; HIV; Human | 1987 |